BRCA1 mutations in primary breast and ovarian carcinomas.

Détails

ID Serval
serval:BIB_AE19EAB0F7B2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
BRCA1 mutations in primary breast and ovarian carcinomas.
Périodique
Science
Auteur⸱e⸱s
Futreal P.A., Liu Q., Shattuck-Eidens D., Cochran C., Harshman K., Tavtigian S., Bennett L.M., Haugen-Strano A., Swensen J., Miki Y., Eddington K., Mcclure M., Frye C., Weaverfeldhaus J., Ding W., Gholami Z., Soderkvist P., Terry L., Jhanwar S., Berchuck A., Iglehart J.D., Marks J., Ballinger D.G., Barrett J.C., Skolnick M.H., Kamb A., Wiseman R.
ISSN
0036-8075[print], 0036-8075[linking]
Statut éditorial
Publié
Date de publication
10/1994
Volume
266
Numéro
5182
Pages
120-122
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S. Publication Status: ppublish
Résumé
Loss of heterozygosity data from familial tumors suggest that BRCA1, a gene that confers susceptibility to ovarian and early-onset breast cancer, encodes a tumor suppressor. The BRCA1 region is also subject to allelic loss in sporadic breast and ovarian cancers, an indication that BRCA1 mutations may occur somatically in these tumors. The BRCA1 coding region was examined for mutations in primary breast and ovarian tumors that show allele loss at the BRCA1 locus. Mutations were detected in 3 of 32 breast and 1 of 12 ovarian carcinomas; all four mutations were germline alterations and occurred in early-onset cancers. These results suggest that mutation of BRCA1 may not be critical in the development of the majority of breast and ovarian cancers that arise in the absence of a mutant germline allele.
Mots-clé
Adult, Age of Onset, Alleles, BRCA1 Protein, Base Sequence, Breast Neoplasms/genetics, Chromosomes, Human, Pair 17, Female, Genes, Tumor Suppressor, Genetic Predisposition to Disease, Germ-Line Mutation, Heterozygote, Humans, Middle Aged, Molecular Sequence Data, Neoplasm Proteins/genetics, Ovarian Neoplasms/genetics, Transcription Factors/genetics
Pubmed
Web of science
Création de la notice
24/01/2008 15:33
Dernière modification de la notice
20/08/2019 15:17
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