Combining Gene Transfer and Nonhuman Primates to Better Understand and Treat Parkinson's Disease.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_AE05ED755F21
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Combining Gene Transfer and Nonhuman Primates to Better Understand and Treat Parkinson's Disease.
Périodique
Frontiers in molecular neuroscience
Auteur⸱e⸱s
Lasbleiz C., Mestre-Francés N., Devau G., Luquin M.R., Tenenbaum L., Kremer E.J., Verdier J.M.
ISSN
1662-5099 (Print)
ISSN-L
1662-5099
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
12
Pages
10
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Parkinson's disease (PD) is a progressive CNS disorder that is primarily associated with impaired movement. PD develops over decades and is linked to the gradual loss of dopamine delivery to the striatum, via the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). While the administration of L-dopa and deep brain stimulation are potent therapies, their costs, side effects and gradual loss of efficacy underlines the need to develop other approaches. Unfortunately, the lack of pertinent animal models that reproduce DA neuron loss and behavior deficits-in a timeline that mimics PD progression-has hindered the identification of alternative therapies. A complementary approach to transgenic animals is the use of nonhuman primates (NHPs) combined with the overexpression of disease-related genes using viral vectors. This approach may induce phenotypes that are not influenced by developmental compensation mechanisms, and that take into account the personality of animals. In this review article, we discuss the combination of gene transfer and NHPs to develop "genetic" models of PD that are suitable for testing therapeutic approaches.
Mots-clé
Molecular Biology, Cellular and Molecular Neuroscience, CAV vectors, Parkinson’s disease, dopaminergic neurons, gene transfer, primate
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/02/2019 17:03
Dernière modification de la notice
20/08/2019 15:17
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