Postmortem diagnosis of anaphylaxis in presence of decompositional changes.

Détails

ID Serval
serval:BIB_ADEC851903DE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Compte-rendu: analyse d'une oeuvre publiée.
Collection
Publications
Institution
Titre
Postmortem diagnosis of anaphylaxis in presence of decompositional changes.
Périodique
Journal of forensic and legal medicine
Auteur(s)
Radheshi E., Reggiani Bonetti L., Confortini A., Silingardi E., Palmiere C.
ISSN
1878-7487 (Electronic)
ISSN-L
1752-928X
Statut éditorial
Publié
Date de publication
02/2016
Peer-reviewed
Oui
Volume
38
Pages
97-100
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication types: Case Reports ; Journal Article

Résumé
Eosinophil and activated mast cell identification in the spleen combined with mast cell tryptase determination in postmortem serum may diagnose fatal anaphylaxis with a high degree of certainty. Mast cell tryptase measurement and significance in corpses with decompositional changes remains however an issue of controversy. Analogously, immunohistochemistry in corpses with decompositional changes may be influenced by several mechanisms, including protein alteration, antigen diffusion and unspecific antibody binding to disrupted protein structures. The authors present an autopsy case involving a 55-year-old woman who unintentionally received clarithromycin. Due to difficult in administrative procedures, the postmortem examination was performed 96 h after death. Mast cell tryptase was measured in postmortem serum from femoral, aortic and right heart blood. The obtained results were consistent with mast cell activation. Histochemistry (Pagoda Red) and immunohistochemistry (anti-tryptase antibodies) allowed splenic eosinophils and mast cells to be detected. Based on the results of all postmortem investigations, the hypothesis of anaphylaxis following accidental clarithromycin administration was formulated.

Mots-clé
Anaphylaxis/chemically induced, Anaphylaxis/diagnosis, Anti-Bacterial Agents/adverse effects, Clarithromycin/adverse effects, Eosinophils/cytology, Female, Forensic Toxicology, Humans, Immunohistochemistry, Mast Cells/metabolism, Medication Errors, Middle Aged, Postmortem Changes, Spleen/cytology, Tryptases/blood
Pubmed
Web of science
Création de la notice
12/01/2016 10:37
Dernière modification de la notice
20/08/2019 16:17
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