α₁-Adrenergic receptors contribute to the acute effects of 3,4-methylenedioxymethamphetamine in humans.

Détails

ID Serval
serval:BIB_AD8F1220F3A2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
α₁-Adrenergic receptors contribute to the acute effects of 3,4-methylenedioxymethamphetamine in humans.
Périodique
Journal of Clinical Psychopharmacology
Auteur⸱e⸱s
Hysek C.M., Fink A.E., Simmler L.D., Donzelli M., Grouzmann E., Liechti M.E.
ISSN
1533-712X (Electronic)
ISSN-L
0271-0749
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
33
Numéro
5
Pages
658-666
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Preclinical studies implicate a role for α₁-noradrenergic receptors in the effects of psychostimulants, including 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). The present study evaluated the effects of the α₁-noradrenergic receptor antagonist doxazosin on the acute pharmacodynamic and pharmacokinetic response to MDMA in 16 healthy subjects. Doxazosin (8 mg/d) or placebo was administered for 3 days before MDMA (125 mg) or placebo using a randomized, double-blind, placebo-controlled, 4-session, crossover design. Doxazosin reduced MDMA-induced elevations in blood pressure, body temperature, and moderately attenuated positive mood but enhanced tachycardia associated with MDMA. The results indicate that α₁-adrenergic receptors contribute to the acute cardiostimulant and to a minor extent possibly also to the thermogenic and euphoric effects of MDMA in humans.
Pubmed
Web of science
Création de la notice
07/03/2014 19:03
Dernière modification de la notice
20/08/2019 16:17
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