Microglial role in the development of chronic pain.

Détails

ID Serval
serval:BIB_ACF886B469B0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Microglial role in the development of chronic pain.
Périodique
Current opinion in anaesthesiology
Auteur(s)
Suter M.R.
ISSN
1473-6500 (Electronic)
ISSN-L
0952-7907
Statut éditorial
Publié
Date de publication
10/2016
Peer-reviewed
Oui
Volume
29
Numéro
5
Pages
584-589
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The review aims to present the latest research into microglia and their role in pain.
Microglia affect sex and age-dependent differences in pain. The various microglial phenotypes make their involvement in pain more complex but provide more potential as pain modulators.
Glial cells, composed of microglia, astrocytes, and oligodendrocytes, outnumber neurons in the central nervous system. The crosstalk between these cells and neurons is now established as participating in the development of chronic pain. There has been a great advance in the description of microglia reactivity from pro to anti-inflammatory phenotypes. The modulation of these phenotypes could be a potential target for pain therapy. Recently, different microglial reactivity between man and woman and between neonates and adults, in response to nerve injury were described, which could explain some of the sex differences in pain sensitivity and the absence of neuropathic pain development in neonates. Clinical trials using microglia as a target have been carried out in various neurological diseases and pain, with limited efficacy in the latter, but there are nonetheless, indications that with some improvement in study strategies microglia could be a future target for pain control.

Mots-clé
Adult, Age Factors, Brain/physiology, Chronic Pain/drug therapy, Chronic Pain/physiopathology, Drug Repositioning, Female, Humans, Infant, Infant, Newborn, Male, Microglia/drug effects, Microglia/physiology, Minocycline/therapeutic use, Neural Pathways/drug effects, Neural Pathways/physiology, Neuralgia/drug therapy, Neuralgia/physiopathology, Nociception/drug effects, Nociception/physiology, Nociceptors/drug effects, Nociceptors/physiology, Pyridones/therapeutic use, Pyrimidines/therapeutic use, Sex Factors, Thiazolidinediones/therapeutic use
Pubmed
Web of science
Création de la notice
12/08/2016 9:17
Dernière modification de la notice
20/08/2019 15:16
Données d'usage