Inflammatory and oxidative stress biomarkers in allergic rhinitis: the effect of smoking.

Détails

ID Serval
serval:BIB_ACF134939A13
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Inflammatory and oxidative stress biomarkers in allergic rhinitis: the effect of smoking.
Périodique
Clinical and experimental allergy
Auteur⸱e⸱s
Tanou K., Koutsokera A., Kiropoulos T.S., Maniati M., Papaioannou A.I., Georga K., Zarogiannis S., Gourgoulianis K.I., Kostikas K.
ISSN
1365-2222 (Electronic)
ISSN-L
0954-7894
Statut éditorial
Publié
Date de publication
03/2009
Peer-reviewed
Oui
Volume
39
Numéro
3
Pages
345-353
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Accumulating evidence confirms the presence of pan-airway inflammation in allergic rhinitis patients. Smoking is known to affect the asthmatic airway inflammation. However, no study has evaluated the impact of smoking on airway inflammation of allergic rhinitis patients.
The aim of the present study was to evaluate the impact of smoking on inflammatory and oxidative stress biomarkers in patients with seasonal allergic rhinitis, using non-invasive methods for sample collection.
Forty patients with seasonal allergic rhinitis (20 smokers and 20 non-smokers) and 30 healthy subjects (15 smokers and 15 non-smokers) were recruited for the study during pollen season. All subjects were submitted to measurement of the fraction of exhaled NO (FeNO), exhaled breath condensate (EBC) collection, nasal lavage collection, pre- and post- bronchodilation spirometry and metacholine bronchial challenge testing. pH, leukotriene B(4) (LTB(4)) and 8-isoprostane were determined in EBC and nasal lavage samples.
Patients with allergic rhinitis presented higher LTB(4) and 8-isoprostane levels in nasal lavage (P<0.0001 for both comparisons), with no significant differences between smokers and non-smokers. Patients with allergic rhinitis also presented higher LTB(4) levels and lower pH in EBC (P<0.001 and P=0.004, respectively), with prominent differences between smokers and non-smokers (P<0.0001 and P=0.003, for LTB(4) and pH, respectively). A significant correlation between nasal lavage and EBC LTB(4) values was observed (r(s)=0.313, P=0.048).
Patients with allergic rhinitis present increased LTB(4) and 8-isoprostane in their nasal cavity, however, with no significant differences between smokers and non-smokers. In contrast, smokers with allergic rhinitis present higher LTB(4) levels and lower pH in EBC, suggesting that these patients may be more susceptible to the deleterious effects of smoking, compared with non-smokers.
Mots-clé
Adult, Biomarkers/analysis, Biomarkers/metabolism, Breath Tests, Dinoprost/analogs & derivatives, Dinoprost/analysis, Dinoprost/metabolism, Eosinophils/cytology, Female, Humans, Hydrogen-Ion Concentration, Immunoglobulin E/blood, Inflammation/metabolism, Leukotriene B4/analysis, Leukotriene B4/metabolism, Male, Nasal Lavage Fluid/chemistry, Nasal Lavage Fluid/cytology, Nitric Oxide/analysis, Nitric Oxide/metabolism, Oxidative Stress, Rhinitis, Allergic, Seasonal/blood, Rhinitis, Allergic, Seasonal/metabolism, Smoking/adverse effects, Smoking/metabolism
Pubmed
Web of science
Création de la notice
19/07/2019 19:44
Dernière modification de la notice
21/08/2019 6:32
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