Clinical review: Optimal dose of continuous renal replacement therapy in acute kidney injury.

Détails

ID Serval
serval:BIB_ACE570B3341D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Clinical review: Optimal dose of continuous renal replacement therapy in acute kidney injury.
Périodique
Critical Care
Auteur⸱e⸱s
Prowle J.R., Schneider A., Bellomo R.
ISSN
1466-609X (Electronic)
ISSN-L
1364-8535
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
15
Numéro
2
Pages
207
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
Continuous renal replacement therapy (CRRT) is the preferred treatment for acute kidney injury in intensive care units (ICUs) throughout much of the world. Despite the widespread use of CRRT, controversy and center-specific practice variation in the clinical application of CRRT continue. In particular, whereas two single-center studies have suggested survival benefit from delivery of higher-intensity CRRT to patients with acute kidney injury in the ICU, other studies have been inconsistent in their results. Now, however, two large multi-center randomized controlled trials - the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network (ATN) study and the Randomized Evaluation of Normal versus Augmented Level (RENAL) Replacement Therapy Study - have provided level 1 evidence that effluent flow rates above 25 mL/kg per hour do not improve outcomes in patients in the ICU. In this review, we discuss the concept of dose of CRRT, its relationship with clinical outcomes, and what target optimal dose of CRRT should be pursued in light of the high-quality evidence now available.
Mots-clé
Acute Kidney Injury/therapy, Dose-Response Relationship, Drug, Evidence-Based Medicine, Humans, Intensive Care/methods, Randomized Controlled Trials as Topic, Renal Replacement Therapy/methods, Treatment Outcome
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/11/2014 22:21
Dernière modification de la notice
20/08/2019 16:16
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