Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.

Détails

Ressource 1Télécharger: bmj.g4164.full.pdf (2862.54 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_ACCDC5E1796D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.
Périodique
BMJ (Clinical research ed.)
Auteur(s)
Holmes M.V., Dale C.E., Zuccolo L., Silverwood R.J., Guo Y., Ye Z., Prieto-Merino D., Dehghan A., Trompet S., Wong A., Cavadino A., Drogan D., Padmanabhan S., Li S., Yesupriya A., Leusink M., Sundstrom J., Hubacek J.A., Pikhart H., Swerdlow D.I., Panayiotou A.G., Borinskaya S.A., Finan C., Shah S., Kuchenbaecker K.B., Shah T., Engmann J., Folkersen L., Eriksson P., Ricceri F., Melander O., Sacerdote C., Gamble D.M., Rayaprolu S., Ross O.A., McLachlan S., Vikhireva O., Sluijs I., Scott R.A., Adamkova V., Flicker L., Bockxmeer F.M., Power C., Marques-Vidal P., Meade T., Marmot M.G., Ferro J.M., Paulos-Pinheiro S., Humphries S.E., Talmud P.J., Mateo Leach I., Verweij N., Linneberg A., Skaaby T., Doevendans P.A., Cramer M.J., van der Harst P., Klungel O.H., Dowling N.F., Dominiczak A.F., Kumari M., Nicolaides A.N., Weikert C., Boeing H., Ebrahim S., Gaunt T.R., Price J.F., Lannfelt L., Peasey A., Kubinova R., Pajak A., Malyutina S., Voevoda M.I., Tamosiunas A., Maitland-van der Zee A.H., Norman P.E., Hankey G.J., Bergmann M.M., Hofman A., Franco O.H., Cooper J., Palmen J., Spiering W., de Jong P.A., Kuh D., Hardy R., Uitterlinden A.G., Ikram M.A., Ford I., Hyppönen E., Almeida O.P., Wareham N.J., Khaw K.T., Hamsten A., Husemoen L.L., Tjønneland A., Tolstrup J.S., Rimm E., Beulens J.W., Verschuren W.M., Onland-Moret N.C., Hofker M.H., Wannamethee S.G., Whincup P.H., Morris R., Vicente A.M., Watkins H., Farrall M., Jukema J.W., Meschia J., Cupples L.A., Sharp S.J., Fornage M., Kooperberg C., LaCroix A.Z., Dai J.Y., Lanktree M.B., Siscovick D.S., Jorgenson E., Spring B., Coresh J., Li Y.R., Buxbaum S.G., Schreiner P.J., Ellison R.C., Tsai M.Y., Patel S.R., Redline S., Johnson A.D., Hoogeveen R.C., Hakonarson H., Rotter J.I., Boerwinkle E., de Bakker P.I., Kivimaki M., Asselbergs F.W., Sattar N., Lawlor D.A., Whittaker J., Davey Smith G., Mukamal K., Psaty B.M., Wilson J.G., Lange L.A., Hamidovic A., Hingorani A.D., Nordestgaard B.G., Bobak M., Leon D.A., Langenberg C., Palmer T.M., Reiner A.P., Keating B.J., Dudbridge F., Casas J.P.
Collaborateur(s)
InterAct Consortium
ISSN
1756-1833 (Electronic)
ISSN-L
0959-535X
Statut éditorial
Publié
Date de publication
10/07/2014
Peer-reviewed
Oui
Volume
349
Pages
g4164
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: epublish

Résumé
To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease.
Mendelian randomisation meta-analysis of 56 epidemiological studies.
261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers.
Odds ratio for coronary heart disease and stroke associated with the ADH1B variant in all individuals and by categories of alcohol consumption.
Carriers of the A-allele of ADH1B rs1229984 consumed 17.2% fewer units of alcohol per week (95% confidence interval 15.6% to 18.9%), had a lower prevalence of binge drinking (odds ratio 0.78 (95% CI 0.73 to 0.84)), and had higher abstention (odds ratio 1.27 (1.21 to 1.34)) than non-carriers. Rs1229984 A-allele carriers had lower systolic blood pressure (-0.88 (-1.19 to -0.56) mm Hg), interleukin-6 levels (-5.2% (-7.8 to -2.4%)), waist circumference (-0.3 (-0.6 to -0.1) cm), and body mass index (-0.17 (-0.24 to -0.10) kg/m(2)). Rs1229984 A-allele carriers had lower odds of coronary heart disease (odds ratio 0.90 (0.84 to 0.96)). The protective association of the ADH1B rs1229984 A-allele variant remained the same across all categories of alcohol consumption (P=0.83 for heterogeneity). Although no association of rs1229984 was identified with the combined subtypes of stroke, carriers of the A-allele had lower odds of ischaemic stroke (odds ratio 0.83 (0.72 to 0.95)).
Individuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health.

Mots-clé
Adult, Aged, Alcohol Dehydrogenase/genetics, Alcohol Drinking/adverse effects, Alcohol Drinking/genetics, Biomarkers/blood, Coronary Disease/blood, Coronary Disease/etiology, Coronary Disease/genetics, Female, Genetic Markers, Genotype, Humans, Male, Mendelian Randomization Analysis, Middle Aged, Models, Statistical, Polymorphism, Single Nucleotide, Stroke/blood, Stroke/etiology, Stroke/genetics
Pubmed
Création de la notice
18/11/2014 15:39
Dernière modification de la notice
20/08/2019 15:16
Données d'usage