Antipyretic effect of parenteral paracetamol (propacetamol) in pediatric oncologic patients: a randomized trial

Détails

ID Serval
serval:BIB_ACCAFD1E3188
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Antipyretic effect of parenteral paracetamol (propacetamol) in pediatric oncologic patients: a randomized trial
Périodique
Pediatric Hematology and Oncology
Auteur(s)
Reymond  D., Birrer  P., Luthy  A. R., Rimensberger  P. C., Beck  M. N.
ISSN
0888-0018
Statut éditorial
Publié
Date de publication
02/1997
Peer-reviewed
Oui
Volume
14
Numéro
1
Pages
51-7
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Jan-Feb
Résumé
The antipyretic efficacy of propacetamol, an intravenous prodrug of paracetamol, was evaluated in two pediatric prospective randomized studies. In the first, we-compared one standard intravenous dose of propacetamol (30 mg/kg) to one standard intravenous dose of acetylsalicylic acid (ASA, 15 mg/kg) in 10 nononcologic patients with bacterial illnesses. In the second study, we compared two intravenous doses of propacetamol (30 mg/kg versus 15 mg/kg) in 24 oncologic patients with fever and neutropenia. No statistically significant differences in antipyretic efficacy were found between standard doses of propacetamol and ASA; even when half-doses of propacetamol (15 mg/kg) were used, good antipyretic efficacy was observed, which was not statistically different from that observed with the full dose. The use of propacetamol seems promising for patients (such as oncologic patients) who cannot receive enteral paracetamol formulas.
Mots-clé
Acetaminophen/adverse effects/*therapeutic use Analgesics, Non-Narcotic/adverse effects/*therapeutic use Aspirin/adverse effects/*therapeutic use Bacterial Infections/complications Child Child, Preschool Fever/*drug therapy/etiology Humans Infusions, Intravenous Neoplasms/*complications Neutropenia/drug therapy/etiology Prospective Studies
Pubmed
Web of science
Création de la notice
20/03/2008 9:34
Dernière modification de la notice
20/08/2019 15:16
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