Laminar analysis of the cerebellar cortex shows widespread damage in early MS patients: A pilot study at 7T MRI.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC 4.0
ID Serval
serval:BIB_AC384373C63F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Laminar analysis of the cerebellar cortex shows widespread damage in early MS patients: A pilot study at 7T MRI.
Périodique
Multiple sclerosis journal - experimental, translational and clinical
Auteur⸱e⸱s
Galbusera R., Parmar K., Boillat Y., Fartaria M.J., Todea A.R., Brien K.O., Smolinski A., Kappos L., van der Zwaag W., Granziera C.
ISSN
2055-2173 (Print)
ISSN-L
2055-2173
Statut éditorial
Publié
Date de publication
2020
Peer-reviewed
Oui
Volume
6
Numéro
4
Pages
2055217320961409
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
To date, little is known about the presence and extent of cerebellar cortical pathology in early stages of MS.
The aims of this study were to (i) investigate microstructural changes in the normal-appearing cerebellar cortex of early MS patients by using 7 T MRI and (ii) evaluate the influence of those changes on clinical performance.
Eighteen RRMS patients and nine healthy controls underwent quantitative T <sub>1</sub> and T <sub>2</sub> * measurement at 7 T MRI using high-resolution MP2RAGE and multi-echo gradient-echo imaging. After subtracting lesion masks, average T <sub>1</sub> and T <sub>2</sub> * maps were computed for three layers in the cerebellar cortex and compared between groups using mixed effects models.
The volume of the cerebellar cortex and its layers did not differ between patients and controls. In MS patients, significantly longer T <sub>1</sub> values were observed in all vermis cortical layers and in the middle and external cortical layer of the cerebellar hemispheres. No between-group differences in T <sub>2</sub> * values were found. T <sub>1</sub> values correlated with EDSS, SDMT and PASAT.
We found MRI evidence of damage in the normal-appearing cerebellar cortex at early MS stages and before volumetric changes. This microstructural alteration appears to be related to EDSS and cognitive performance.
Mots-clé
MRI, Multiple sclerosis, cerebellum, ultra-high field MRI
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/11/2020 11:56
Dernière modification de la notice
09/08/2024 15:04
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