Sister cytotoxic CD8+ T cell clones differing in natural killer inhibitory receptor expression in human astrocytoma
Détails
ID Serval
serval:BIB_AC243B538799
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sister cytotoxic CD8+ T cell clones differing in natural killer inhibitory receptor expression in human astrocytoma
Périodique
Immunology Letters
ISSN
0165-2478 (Print)
Statut éditorial
Publié
Date de publication
04/2002
Volume
81
Numéro
2
Pages
125-32
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr 22
Research Support, Non-U.S. Gov't --- Old month value: Apr 22
Résumé
Natural killer (NK) inhibitory receptors are thought to play a critical role in the regulation of cytotoxicity of NK cells and certain self-reactive T cells. In the present study, we investigated whether astrocytoma infiltrating T lymphocytes may be functionally compromised by NK receptors (NKRs). The NK inhibitory receptor CD94/NKG2A was found on a significant proportion of CD8+ astrocytoma infiltrating lymphocytes. The functional consequences of CD94/NKG2A expression were explored at the clonal level, using a T cell clone that exhibited substantial variation in the expression of this heterodimer. Triggering of CD94/NKG2A inhibited the killing properties of T cells with a high level of this receptor, but not those from T cells with a low level. Our data indicate that some astrocytoma infiltrating lymphocytes express functional inhibitory CD94/NKG2A, raising the possibility that they may represent silent T cells specific for self-antigens (Ags) expressed on tumor cells. Understanding the mechanisms of regulation of these receptors may bring new insights for optimizing an anti-tumor immune response.
Mots-clé
Antigens, CD/biosynthesis/*immunology
Antigens, CD94
Astrocytoma/*immunology
Humans
Killer Cells, Natural/*immunology
*Lectins, C-Type
Membrane Glycoproteins/biosynthesis/*immunology
Receptors, Antigen, T-Cell, alpha-beta/immunology
Receptors, Immunologic/biosynthesis/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Tumor Cells, Cultured
Pubmed
Web of science
Création de la notice
28/01/2008 11:33
Dernière modification de la notice
20/08/2019 15:16