Improvement of drug-induced chronic renal failure in lung transplantation.

Détails

ID Serval
serval:BIB_ABE6F487C4D3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Lettre (letter): communication adressée à l'éditeur.
Collection
Publications
Titre
Improvement of drug-induced chronic renal failure in lung transplantation.
Périodique
Transplantation
Auteur(s)
Soccal P.M., Gasche Y., Favre H., Spiliopoulos A., Nicod L.P.
ISSN
0041-1337[print], 0041-1337[linking]
Statut éditorial
Publié
Date de publication
1999
Volume
68
Numéro
1
Pages
164-165
Langue
anglais
Notes
Publication types: Letter
Résumé
BACKGROUND: Nephrotoxicity is a frequently encountered adverse effect of calcineurin inhibitors (cyclosporine and tacrolimus)-combined immunosuppressive regimens. METHODS: We have compared the glomerular filtration rate in 14 patients who underwent lung transplantation, before and after replacement of azathioprine by mycophenolate mofetil and reduction of associated calcineurin inhibitors doses. RESULTS: After a mean follow-up of 16+/-4 months with the modified immunosuppressive regimen, the mean glomerular filtration rate increased by 20% with no change in lung function. CONCLUSION: By its strong immunosuppressive effect, mycophenolate mofetil allows the decrease of associated calcineurin inhibitor doses, with subsequent improvement of renal function without jeopardizing the transplanted lung.
Mots-clé
Calcineurin/antagonists & inhibitors, Cyclosporine/adverse effects, Glomerular Filtration Rate/drug effects, Humans, Immunosuppressive Agents/adverse effects, Kidney Failure, Chronic/chemically induced, Lung Transplantation, Mycophenolic Acid/administration & dosage, Mycophenolic Acid/adverse effects, Tacrolimus/adverse effects
Pubmed
Web of science
Création de la notice
19/02/2010 19:50
Dernière modification de la notice
20/08/2019 16:15
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