The limits of brain determinacy.

Détails

ID Serval
serval:BIB_ABD3A00DDC81
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The limits of brain determinacy.
Périodique
Proceedings. Biological Sciences / the Royal Society
Auteur⸱e⸱s
Clarke P.G.
ISSN
1471-2954 (Electronic)
ISSN-L
0962-8452
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
279
Numéro
1734
Pages
1665-1674
Langue
anglais
Notes
Publication types: Journal Article ; Review
Résumé
The genes do not control everything that happens in a cell or an organism, because thermally induced molecular movements and conformation changes are beyond genetic control. The importance of uncontrolled events has been argued from the differences between isogenic organisms reared in virtually identical environments, but these might alternatively be attributed to subtle, undetected differences in the environment. The present review focuses on the uncontrolled events themselves in the context of the developing brain. These are considered at cellular and circuit levels because even if cellular physiology was perfectly controlled by the genes (which it is not), the interactions between different cells might still be uncoordinated. A further complication is that the brain contains mechanisms that buffer noise and others that amplify it. The final resultant of the battle between these contrary mechanisms is that developmental stochasticity is sufficiently low to make neurobehavioural defects uncommon, but a chance component of neural development remains. Thus, our brains and behaviour are not entirely determined by a combination of genes-plus-environment.
Mots-clé
Animals, Brain/embryology, Environment, Gene Expression Regulation, Developmental, Humans, Neurons/cytology, Noise, Stochastic Processes
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/10/2012 13:50
Dernière modification de la notice
20/08/2019 15:15
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