In vivo cytogenetic studies of the genotoxic effects of polymethyl methacrylate employed in orthopaedics.

Détails

ID Serval
serval:BIB_ABBB0F4C0429
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
In vivo cytogenetic studies of the genotoxic effects of polymethyl methacrylate employed in orthopaedics.
Périodique
Journal of Materials Science
Auteur(s)
Lamberti L., Bigatti P., Rizzi P., Marchisio S., Rizzo E., Cannas M.
ISSN
0957-4530
Statut éditorial
Publié
Date de publication
04/1998
Peer-reviewed
Oui
Volume
9
Numéro
4
Pages
239-242
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Polymethyl methacrylate (PMMA) is a material employed as a cement in prosthesis that has been found to induce cytogenetic damage in human lymphocytes in vitro. This effect is particularly achieved before the 5th day of the exposition, while after this period no significant variations appeared. In the present study, results of cytogenetic tests in humans are reported. Sister chromatid exchange analysis and micronucleus tests have been performed on lymphocytes of patients who had undergone prosthesization with cemented prosthesis (group A) or with biological anchorage prosthesis, as control (group B). DNA damage was investigated before implantation and 5 d after surgery in both groups. Cytogenetic tests did not show any significant increase in the number of micronuclei and sister chromatid exchanges with respect to control values in patients with PMMA cemented prosthesis.
Pubmed
Web of science
Création de la notice
08/07/2008 12:03
Dernière modification de la notice
20/08/2019 16:15
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