In vivo T-lymphocyte tolerance in the absence of thymic clonal deletion mediated by hematopoietic cells.

Détails

ID Serval
serval:BIB_ABAF895F08F0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
In vivo T-lymphocyte tolerance in the absence of thymic clonal deletion mediated by hematopoietic cells.
Périodique
Blood
Auteur⸱e⸱s
van Meerwijk J.P., MacDonald H.R.
ISSN
0006-4971
Statut éditorial
Publié
Date de publication
1999
Peer-reviewed
Oui
Volume
93
Numéro
11
Pages
3856-3862
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Thymic negative selection renders the developing T-cell repertoire tolerant to self-major histocompatability complex (MHC)/peptide ligands. The major mechanism of induction of self-tolerance is thought to be thymic clonal deletion, ie, the induction of apoptotic cell death in thymocytes expressing a self-reactive T-cell receptor. Consistent with this hypothesis, in mice deficient in thymic clonal deletion mediated by cells of hematopoietic origin, a twofold to threefold increased generation of mature thymocytes has been observed. Here we describe the analysis of the specificity of T lymphocytes developing in the absence of clonal deletion mediated by hematopoietic cells. In vitro, targets expressing syngeneic MHC were readily lysed by activated CD8(+) T cells from deletion-deficient mice. However, proliferative responses of T cells from these mice on activation with syngeneic antigen presenting cells were rather poor. In vivo, deletion-deficient T cells were incapable of induction of lethal graft-versus-host disease in syngeneic hosts. These data indicate that in the absence of thymic deletion mediated by hematopoietic cells functional T-cell tolerance can be induced by nonhematopoietic cells in the thymus. Moreover, our results emphasize the redundancy in thymic negative selection mechanisms.
Mots-clé
Animals, Antigen Presentation, Cell Differentiation/immunology, Hematopoietic Stem Cells/immunology, Immune Tolerance, Major Histocompatibility Complex/immunology, Mice, Mice, Inbred C57BL, T-Lymphocytes/immunology, Thymus Gland/cytology, Thymus Gland/immunology
Pubmed
Web of science
Création de la notice
11/02/2010 10:38
Dernière modification de la notice
20/08/2019 15:15
Données d'usage