Ritonavir plus saquinavir versus single protease inhibitor therapy in protease inhibitor-naive HIV-infected patients: the Swiss HIV Cohort Study

Détails

ID Serval
serval:BIB_AB90EBCEB2FA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Ritonavir plus saquinavir versus single protease inhibitor therapy in protease inhibitor-naive HIV-infected patients: the Swiss HIV Cohort Study
Périodique
HIV Medicine
Auteur⸱e⸱s
Bucher  H. C., Bichsel  M., Taffe  P., Furrer  H., Telenti  A., Hirschel  B., Weber  R., Bernasconi  E., Vernazza  P., Minder  C., Battegay  M.
ISSN
1464-2662 (Print)
Statut éditorial
Publié
Date de publication
10/2002
Volume
3
Numéro
4
Pages
247-53
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
OBJECTIVES: To compare the response to ritonavir (RTV) plus saquinavir (SQV) with single protease inhibitor (PI) therapies among PI-naive HIV-1 infected individuals. METHODS: Response to treatment was analysed according to the intent-to-treat principle in a prospective observational cohort study of 177 patients who between May 1995 and March 2000 started a double PI therapy with RTV and SQV (nonboosting dosages) plus at least one nucleoside reverse transcriptase inhibitor (NRTI) and 2,214 patients with a single PI therapy plus two NRTIs. We used survival analysis and Cox's proportional hazard regression methods. The primary endpoint was the time to a plasma viral load of < 400 copies/mL. Secondary endpoints were taken as a gain in the CD4 count of >100 cells/microL, and change of initial PI for any reason. RESULTS: Baseline characteristics in both treatment groups were balanced. Median follow-up in both groups was 10.4 months. Time to an HIV-1 viral load of < 400 copies/mL and an increase in the CD4 count of >100 x 10(6) cells/L was shorter for RTV plus SQV compared with single PI regimens (log rank test for each endpoint P < 0.05). The adjusted hazard ratios of RTV plus SQV compared with single PI regimens were 1.21 (95% confidence interval 0.99-1.47) for achieving an HIV-1 viral load of < 400 copies/mL, 1.12 (0.88-1.42) for an increase in the CD4 count of > 100 cells/microL, and 0.90 (0.73-1.11) for change of first PI regimen. CONCLUSIONS: Treatment with RTV plus SQV compared with single PI regimens appeared to give similar results for virological or immunological response.
Mots-clé
Adolescent Adult Aged Aged, 80 and over CD4 Lymphocyte Count Cohort Studies Drug Therapy, Combination Female Follow-Up Studies HIV Infections/*drug therapy HIV Protease Inhibitors/*administration & dosage Humans Male Middle Aged Prospective Studies RNA, Viral/blood Reverse Transcriptase Inhibitors/*administration & dosage Ritonavir/*administration & dosage Saquinavir/*administration & dosage Viral Load
Pubmed
Création de la notice
25/01/2008 15:46
Dernière modification de la notice
20/08/2019 16:15
Données d'usage