Biodistribution of ultrasmall iron oxide particles in the rat liver.

Détails

ID Serval
serval:BIB_AAA033741622
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Biodistribution of ultrasmall iron oxide particles in the rat liver.
Périodique
Journal of Magnetic Resonance Imaging : Jmri
Auteur(s)
Van Beers B.E., Sempoux C., Materne R., Delos M., Smith A.M.
ISSN
1053-1807 (Print)
ISSN-L
1053-1807
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
13
Numéro
4
Pages
594-599
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Ferumoxtran, an ultrasmall superparamagnetic iron oxide particle, can be located in several tissue compartments in the liver, namely the extracellular space (blood and interstitium), reticuloendothelial cells, and possibly hepatocytes. To better understand the compartmental distribution of ferumoxtran in the liver, we performed a longitudinal study in the rat using microscopy and magnetic resonance imaging. At light microscopy, no substantial cellular uptake of ferumoxtran was observed before one hour after injection. With a dose of 15 micromol Fe/kg, the number of ferumoxtran particles in the reticuloendothelial cells peaked between one and four hours and with a 150 micromol Fe/kg dose, it peaked between eight and 24 hours. Within hepatocytes, only sparse particles were observed with electron microscopy, at a dose of 150 micromol Fe/kg. Imaging performed up until one hour after ferumoxtran injection showed a significant increase in liver signal intensity on T1-weighted images. These results suggest that ferumoxtran mainly acts as an extracellular agent for at least one hour in the rat and that reticuloendothelial accumulation peaks at later time points. Substantial uptake within hepatocytes did not occur.
Mots-clé
Animals, Contrast Media/pharmacokinetics, Dextrans, Ferrosoferric Oxide, Iron/pharmacokinetics, Liver/metabolism, Magnetic Resonance Imaging, Magnetite Nanoparticles, Male, Microscopy, Electron, Scanning Transmission, Oxides/pharmacokinetics, Particle Size, Rats, Rats, Wistar
Pubmed
Web of science
Création de la notice
20/10/2016 16:32
Dernière modification de la notice
20/08/2019 15:14
Données d'usage