Chemical Functionalization of Bioceramics To Enhance Endothelial Cells Adhesion for Tissue Engineering.

Détails

ID Serval
serval:BIB_AA531B9ED208
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Chemical Functionalization of Bioceramics To Enhance Endothelial Cells Adhesion for Tissue Engineering.
Périodique
Journal of Medicinal Chemistry
Auteur(s)
Borcard F., Staedler D., Comas H., Juillerat F.K., Sturzenegger P.N., Heuberger R., Gonzenbach U.T., Juillerat-Jeanneret L., Gerber-Lemaire S.
ISSN
1520-4804 (Electronic)
ISSN-L
0022-2623
Statut éditorial
Publié
Date de publication
09/2012
Volume
55
Numéro
18
Pages
7988-7997
Langue
anglais
Notes
Publication types: JOURNAL ARTICLE
Résumé
To control the selective adhesion of human endothelial cells and human serum proteins to bioceramics of different compositions, a multifunctional ligand containing a cyclic arginine-glycine-aspartate (RGD) peptide, a tetraethylene glycol spacer, and a gallate moiety was designed, synthesized, and characterized. The binding of this ligand to alumina-based, hydroxyapatite-based, and calcium phosphate-based bioceramics was demonstrated. The conjugation of this ligand to the bioceramics induced a decrease in the nonselective and integrin-selective binding of human serum proteins, whereas the binding and adhesion of human endothelial cells was enhanced, dependent on the particular bioceramics.
Pubmed
Web of science
Création de la notice
27/09/2012 9:03
Dernière modification de la notice
20/10/2020 10:08
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