Foam pore size is a critical interface parameter of suction-based wound healing devices.

Détails

ID Serval
serval:BIB_AA471E4E998C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Foam pore size is a critical interface parameter of suction-based wound healing devices.
Périodique
Plastic and Reconstructive Surgery
Auteur⸱e⸱s
Heit Y.I., Dastouri P., Helm D.L., Pietramaggiori G., Younan G., Erba P., Münster S., Orgill D.P., Scherer S.S.
ISSN
1529-4242 (Electronic)
Statut éditorial
Publié
Date de publication
2012
Volume
129
Numéro
3
Pages
589-597
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
BACKGROUND: Suction-based wound healing devices with open-pore foam interfaces are widely used to treat complex tissue defects. The impact of changes in physicochemical parameters of the wound interfaces has not been investigated.
METHODS: Full-thickness wounds in diabetic mice were treated with occlusive dressing or a suction device with a polyurethane foam interface varying in mean pore size diameter. Wound surface deformation on day 2 was measured on fixed tissues. Histologic cross-sections were analyzed for granulation tissue thickness (hematoxylin and eosin), myofibroblast density (α-smooth muscle actin), blood vessel density (platelet endothelial cell adhesion molecule-1), and cell proliferation (Ki67) on day 7.
RESULTS: Polyurethane foam-induced wound surface deformation increased with polyurethane foam pore diameter: 15 percent (small pore size), 60 percent (medium pore size), and 150 percent (large pore size). The extent of wound strain correlated with granulation tissue thickness that increased 1.7-fold in small pore size foam-treated wounds, 2.5-fold in medium pore size foam-treated wounds, and 4.9-fold in large pore size foam-treated wounds (p < 0.05) compared with wounds treated with an occlusive dressing. All polyurethane foams increased the number of myofibroblasts over occlusive dressing, with maximal presence in large pore size foam-treated wounds compared with all other groups (p < 0.05).
CONCLUSIONS: The pore size of the interface material of suction devices has a significant impact on the wound healing response. Larger pores increased wound surface strain, tissue growth, and transformation of contractile cells. Modification of the pore size is a powerful approach for meeting biological needs of specific wounds.
Mots-clé
Animals, Male, Mice, Mice, Inbred C57BL, Physicochemical Phenomena, Polyurethanes, Porosity, Suction/instrumentation, Wound Healing
Pubmed
Web of science
Création de la notice
21/03/2012 17:23
Dernière modification de la notice
20/08/2019 15:14
Données d'usage