[Minoxidil in treatment resistant hypertension]

Détails

ID Serval
serval:BIB_A9E6733154A1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
[Minoxidil in treatment resistant hypertension]
Périodique
Schweizerische Medizinische Wochenschrift
Auteur⸱e⸱s
Tenschert  W., Vetter  W., Studer  A., Reuteler  H., Furrer  J., Nussberger  J., Siegenthaler  W.
ISSN
0036-7672 (Print)
Statut éditorial
Publié
Date de publication
12/1979
Volume
109
Numéro
47
Pages
1869-73
Notes
English Abstract
Journal Article --- Old month value: Dec 8
Résumé
22 patients (4 female, 18 male, mean age 47 +/- 10.7 years) with severe essential hypertension (n = 21) and renovascular hypertension (n = 1) were treated with a mean daily dosage of 16.3 +/- 5.1 mg minoxidil for up to 42 weeks. In addition, all patients received a diuretic (hydrochlorothiazide or furosemide) and a beta-blocker (pindolol or propranolol). 8 patients were treated simultaneously with alpha-methyl-dopa. Within one week minoxidil led to a significant reduction in both systolic and diastolic supine blood pressure (p less than or equal to 0.005) from 201.3 +/- 29.0/125.4 +/- 19.2 mm Hg to 172.8 +/- 28.3/106.0 +/- 19.9 mm Hg. The maximum initial blood pressure response was observed after 3 weeks with a mean daily dosage of 12.2 +/- 9.4 mg of minoxidil (160.5 +/- 20.7/99.4 +/- 13.8 MM Hg, p less than or equal to 0.001). Throughout the remaining period a constant and significant reduction in supine systolic and diastolic and upright diastolic blood pressure was achieved (p less than 0.005-less than 0.001) whereas at times systolic blood pressure values could not be lowered significantly. Body weight and pulse rate showed no significant changes throughout the study. In some cases furosemide had to be added by up to 500 mg/day to counteract minoxidil induced water and salt retention. Only moderate doses of beta-blockers were required to prevent a drug induced rise in pulse rate. In these patients a significant change in renal function was not observed. The results show that minoxidil is a potent drug in the treatment of severe essential hypertension.
Mots-clé
Adult Diuretics/therapeutic use Drug Evaluation Drug Therapy, Combination Female Humans Hypertension/*drug therapy Hypertension, Renal/*drug therapy Hypertension, Renovascular/*drug therapy Male Methyldopa/therapeutic use Middle Aged Minoxidil/*therapeutic use Pindolol/therapeutic use Propranolol/therapeutic use Pyrimidines/*therapeutic use
Pubmed
Web of science
Création de la notice
05/03/2008 17:40
Dernière modification de la notice
20/08/2019 16:14
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