Design, data management, and population baseline characteristics of the PERFORM magnetic resonance imaging project.

Détails

Ressource 1Télécharger: BIB_A9DF33153F10.P001.pdf (522.85 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_A9DF33153F10
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Design, data management, and population baseline characteristics of the PERFORM magnetic resonance imaging project.
Périodique
Journal of Neurology
Auteur(s)
Maeder P., Bracoud L., Chabriat H., Gass A., Michel P., Hennerici M.
ISSN
1432-1459 (Electronic)
ISSN-L
0340-5354
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
258
Numéro
5
Pages
795-803
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Quantitative information from magnetic resonance imaging (MRI) may substantiate clinical findings and provide additional insight into the mechanism of clinical interventions in therapeutic stroke trials. The PERFORM study is exploring the efficacy of terutroban versus aspirin for secondary prevention in patients with a history of ischemic stroke. We report on the design of an exploratory longitudinal MRI follow-up study that was performed in a subgroup of the PERFORM trial. An international multi-centre longitudinal follow-up MRI study was designed for different MR systems employing safety and efficacy readouts: new T2 lesions, new DWI lesions, whole brain volume change, hippocampal volume change, changes in tissue microstructure as depicted by mean diffusivity and fractional anisotropy, vessel patency on MR angiography, and the presence of and development of new microbleeds. A total of 1,056 patients (men and women ≥ 55 years) were included. The data analysis included 3D reformation, image registration of different contrasts, tissue segmentation, and automated lesion detection. This large international multi-centre study demonstrates how new MRI readouts can be used to provide key information on the evolution of cerebral tissue lesions and within the macrovasculature after atherothrombotic stroke in a large sample of patients.
Mots-clé
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use, Aspirin/therapeutic use, Female, Humans, Image Interpretation, Computer-Assisted/methods, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Naphthalenes/therapeutic use, Propionates/therapeutic use, Randomized Controlled Trials as Topic, Research Design, Secondary Prevention, Stroke/pathology, Stroke/prevention & control
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2011 11:57
Dernière modification de la notice
20/08/2019 16:14
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