Determinants of peak trabecular bone density in women: the role of androgens, estrogen, and exercise
Détails
ID Serval
serval:BIB_A9961954D673
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Determinants of peak trabecular bone density in women: the role of androgens, estrogen, and exercise
Périodique
Journal of Bone and Mineral Research
ISSN
0884-0431 (Print)
Statut éditorial
Publié
Date de publication
12/1988
Volume
3
Numéro
6
Pages
673-80
Notes
Journal Article --- Old month value: Dec
Résumé
To elucidate determinants of peak trabecular bone density, we studied the role of androgens, estrogen, and aerobic exercise in 30 women from 18 to 22 years old. The women were divided into three groups: Sedentary, 11 normal women who did not exercise regularly; eumenorrheic, 10 athletes with normal menstrual function; and oligomenorrheic, 9 athletes with exercise-induced oligomenorrhea. All athletes participated in aerobic sports that did not involve selective resistance loading of the back. Serum free and albumin-bound testosterone (fab T), androstenedione (A), and estradiol (E2) were measured on four separate occasions at consecutive 7 day intervals and averaged. Trabecular density was measured by quantitative computed tomography of the lumbar spine. Peak trabecular bone density was related to fab T (r = 0.48, p = 0.007), A (r = 0.40, p = 0.03), and E2 (r = 0.40, p = 0.04). When taken in combination, androgens and estrogen each accounted independently for significant portions of the variance in bone density [fab T and E2 (R2 = 0.38, p = 0.002) and A and E2 (R2 = 0.27, p = 0.01)]. Bone density (mg/ml, mean +/- standard error of the mean, SEM) in the sedentary group (174 +/- 6) was not significantly different from that in the eumenorrheic (183 +/- 12, p = 0.47) or oligomenorrheic (161 +/- 11, p = 0.32) subjects. We conclude that androgens and estrogen function as independent and additive determinants of peak trabecular bone density in young women. The quantitative impact of aerobic exercise (without resistance loading) and exercise-induced menstrual dysfunction appears to be less important than that of the hormones.
Mots-clé
Adolescent
Adult
Androgens/*physiology
Bone and Bones/*analysis
Estrogens/*physiology
*Exercise
Female
Humans
Lumbar Vertebrae/analysis
Menstruation Disturbances/metabolism
Nutritional Status
Pituitary Hormones/physiology
Progesterone/physiology
Pubmed
Web of science
Création de la notice
25/01/2008 9:50
Dernière modification de la notice
20/08/2019 15:13