Influence of interleukin-1 receptor antagonist gene polymorphism on disease

Détails

ID Serval
serval:BIB_A983763E1B8F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Influence of interleukin-1 receptor antagonist gene polymorphism on disease
Périodique
Clinical Infectious Diseases
Auteur⸱e⸱s
Witkin  S. S., Gerber  S., Ledger  W. J.
ISSN
1537-6591 (Electronic)
Statut éditorial
Publié
Date de publication
01/2002
Volume
34
Numéro
2
Pages
204-9
Notes
Journal Article
Review --- Old month value: Jan 15
Résumé
Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring competitive inhibitor of interleukin-1 (IL-1)-induced proinflammatory activity. The IL-1RA gene is polymorphic, resulting in quantitative differences in both IL-1RA and IL-1beta production. Persons homozygous for allele 2 of the IL-1RA gene (IL1RN*2) have a more prolonged and more severe proinflammatory immune response than persons with other IL-1RA genotypes. Thus, being IL1RN*2 homozygous might be beneficial when combating infectious agents or malignantly transformed cells, but it might be detrimental for those with chronic inflammatory conditions or who are pregnant. The IL1RN*2 phenotype is associated with ulcerative colitis and Crohn's disease, lupus erythematosus, vulvar vestibulitis, and possibly with osteoporosis and coronary artery disease. IL1RN*2 homozygosity may also be associated with recurrent spontaneous abortion, preterm birth, and severity of preeclampsia. Conversely, there are negative associations between IL1RN*2 homozygosity and vaginal colonization with mycoplasmas, infection with human cytomegalovirus and Epstein-Barr virus, human immunodeficiency virus proliferation, and the occurrence of ovarian cancer.
Mots-clé
Animals Genetic Predisposition to Disease Humans Interleukin 1 Receptor Antagonist Protein Polymorphism, Genetic/*genetics Receptors, Interleukin-1/antagonists & inhibitors Sialoglycoproteins/*genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 16:44
Dernière modification de la notice
20/08/2019 16:13
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