Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species.

Détails

ID Serval
serval:BIB_A97284E556D3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species.
Périodique
Acs Medicinal Chemistry Letters
Auteur⸱e⸱s
Sanguinetti M., Sanfilippo S., Castagnolo D., Sanglard D., Posteraro B., Donzellini G., Botta M.
ISSN
1948-5875 (Electronic)
ISSN-L
1948-5875
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
4
Numéro
9
Pages
852-857
Langue
anglais
Notes
Publication types: Journal Article Publication Status: epublish
Résumé
Novel macrocyclic amidinourea derivatives 11, 18, and 25 were synthesized and evaluated as antifungal agents against wild-type and fluconazole resistant Candida species. Macrocyclic compounds 11 and 18 were synthesized through a convergent approach using as a key step a ring-closing metathesis macrocyclization reaction, whereas compounds 25 were obtained by our previously reported synthetic pathway. All the macrocyclic amidinoureas showed antifungal activity toward different Candida species higher or comparable to fluconazole and resulted highly active against fluconazole resistant Candida strains showing in many cases minimum inhibitory concentration values lower than voriconazole.
Pubmed
Web of science
Création de la notice
18/10/2014 16:01
Dernière modification de la notice
20/08/2019 16:13
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