International survey on anticoagulation and antiplatelet strategies after pediatric liver transplantation.

Détails

ID Serval
serval:BIB_A95A60976B91
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
International survey on anticoagulation and antiplatelet strategies after pediatric liver transplantation.
Périodique
Pediatric transplantation
Auteur⸱e⸱s
Calinescu A.M., Karam O., Wilde JCH, Ansari M., McLin V.A., Wildhaber B.E.
ISSN
1399-3046 (Electronic)
ISSN-L
1397-3142
Statut éditorial
Publié
Date de publication
02/2019
Peer-reviewed
Oui
Volume
23
Numéro
1
Pages
e13317
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
In pediatric LT, anticoagulants and antiplatelet agents are regularly used to reduce the risk of vascular thrombosis. As evidence for optimal strategy is lacking, local practices vary greatly. The present survey aimed to compile an international overview of anticoagulation and antiplatelet strategies in pediatric LT. An online survey was sent to 98 pediatric LT centers in North and South America, Europe, Asia, and Australia. Twenty-four centers answered the survey. 20/24 (83%) use some sort of anticoagulation and antiplatelet therapy, yielding 20 different strategies. Perioperative vascular problems, size of the hepatic artery, and patient weight were the most frequent determinants of changes in anticoagulant and antiplatelet strategy. Early HAT rates were reported to be 5% or less in 79% of responding centers. Anticoagulation and antiplatelet strategies were not significantly associated with early HAT rates (P = 0.63), or with the number of pediatric LTs performed per year and center (P = 0.92). Internationally, there is a wide variety in anticoagulation and antiplatelet strategies after pediatric LT. Efforts must be made to design a prospective multicentric trial to identify the optimal antithrombotic strategy.
Mots-clé
anticoagulation, hepatic artery thrombosis, pediatric liver transplantation
Pubmed
Open Access
Oui
Création de la notice
24/01/2019 14:59
Dernière modification de la notice
20/08/2019 15:13
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