The regulation of iron homeostasis in the fungal human pathogen Candida glabrata.

Détails

Ressource 1Télécharger: Devaux et Thiébaut - 2019 - The regulation of iron homeostasis in the fungal h.pdf (3370.05 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY-NC 4.0
ID Serval
serval:BIB_A9478A399AD1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The regulation of iron homeostasis in the fungal human pathogen Candida glabrata.
Périodique
Microbiology
Auteur⸱e⸱s
Devaux F., Thiébaut A.
ISSN
1465-2080 (Electronic)
ISSN-L
1350-0872
Statut éditorial
Publié
Date de publication
10/2019
Peer-reviewed
Oui
Volume
165
Numéro
10
Pages
1041-1060
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Iron is an essential element to most microorganisms, yet an excess of iron is toxic. Hence, living cells have to maintain a tight balance between iron uptake and iron consumption and storage. The control of intracellular iron concentrations is particularly challenging for pathogens because mammalian organisms have evolved sophisticated high-affinity systems to sequester iron from microbes and because iron availability fluctuates among the different host niches. In this review, we present the current understanding of iron homeostasis and its regulation in the fungal pathogen Candida glabrata. This yeast is an emerging pathogen which has become the second leading cause of candidemia, a life-threatening invasive mycosis. C. glabrata is relatively poorly studied compared to the closely related model yeast Saccharomyces cerevisiae or to the pathogenic yeast Candida albicans. Still, several research groups have started to identify the actors of C. glabrata iron homeostasis and its transcriptional and post-transcriptional regulation. These studies have revealed interesting particularities of C. glabrata and have shed new light on the evolution of fungal iron homeostasis.
Mots-clé
evolution,iron,regulatory networks,yeast, evolution, iron, regulatory networks, yeast
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/01/2020 13:58
Dernière modification de la notice
23/01/2020 6:26
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