The role of radiotherapy in the treatment of subtotally resected benign meningiomas

Détails

ID Serval
serval:BIB_A93056456D63
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The role of radiotherapy in the treatment of subtotally resected benign meningiomas
Périodique
Journal of Neuro-Oncology
Auteur(s)
Miralbell  R., Linggood  R. M., de la Monte  S., Convery  K., Munzenrider  J. E., Mirimanoff  R. O.
ISSN
0167-594X (Print)
Statut éditorial
Publié
Date de publication
06/1992
Volume
13
Numéro
2
Pages
157-64
Notes
Journal Article --- Old month value: Jun
Résumé
Thirty-six patients with benign meningioma were treated for primary or recurrent disease by subtotal resection and external beam irradiation from 1968-1986 at Massachusetts General Hospital. Comparison is made with 79 patients treated by subtotal surgery alone from 1962-1980. Progression-free survival for 17 patients irradiated after initial incomplete surgery was 88% at 8 years compared with 48% for similar patients treated by surgery alone (p = 0.057). 16 patients incompletely resected at time of first recurrence were irradiated and 78% were progression-free at 8 years while 11% of a similar group treated by surgery alone were progression free (p = 0.001). Long term overall survival was high and similar in both control and study groups. Two patients were irradiated at second recurrence and 1 patient at third recurrence. Twenty-five patients were treated with photons alone and have a median follow-up of 57 months, 6 patients have recurred at doses 45-60 Gy. Eleven patients were treated with combined 10 MV photons and 160 MV protons utilizing 3-D treatment planning. These patients have been followed for a median of 53 months and none have failed to date. Eight of 11 received 54-60.4 Gy and 3/11 greater than 64.48 Gy. Sex, age, pathology grade and score, surgery and timing of radiation therapy were not associated with significant differences in failure patterns within the irradiated study group (p less than 0.1). Complications have been seen in 6 irradiated patients.
Mots-clé
Adolescent Adult Aged Female Humans Life Tables Male Meningeal Neoplasms/epidemiology/*radiotherapy/surgery Meningioma/epidemiology/*radiotherapy/surgery Middle Aged Neoplasm Recurrence, Local Prevalence *Radiotherapy, High-Energy/adverse effects Remission Induction Salvage Therapy Treatment Outcome
Pubmed
Web of science
Création de la notice
24/01/2008 18:12
Dernière modification de la notice
20/08/2019 16:13
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