The spectrum of opportunistic diseases complicating sarcoidosis.

Détails

ID Serval
serval:BIB_A8FE4384EF7C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The spectrum of opportunistic diseases complicating sarcoidosis.
Périodique
Autoimmunity Reviews
Auteur(s)
Jamilloux Y., Valeyre D., Lortholary O., Bernard C., Kerever S., Lelievre L., Neel A., Broussolle C., Seve P.
ISSN
1873-0183 (Electronic)
ISSN-L
1568-9972
Statut éditorial
Publié
Date de publication
2014
Volume
14
Numéro
1
Pages
64-74
Langue
anglais
Résumé
Sarcoidosis is an inflammatory disease marked by a paradoxical immune status. The anergic state, which results from various immune defects, contrasts with the inflammatory formation of granulomas. Sarcoidosis patients may be at risk for opportunistic infections (OIs) and a substantial number of cases have been reported, even in untreated sarcoidosis. It is not clear how OIs in patients with sarcoidosis are different from other groups at risk. In this review, we discuss the most common OIs: mycobacterial infection (including tuberculosis), cryptococcosis, progressive multifocal leukoencephalopathy, and aspergillosis. Unlike peripheral lymphocytopenia, corticosteroids are a major risk factor for OIs but the occurrence of Ols in untreated patients suggests more complex predisposing mechanisms. Opportunistic infections presenting with extrapulmonary features are often misdiagnosed as new localizations of sarcoidosis. Aspergillomas mostly develop on fibrocystic lungs. Overall, physicians should be aware of the possible occurrence of OIs during sarcoidosis, even in untreated patients.
Mots-clé
Opportunistic infections, Sarcoidosis, Tuberculosis, Cryptococcosis, Progressive multifocal leukoencephalopathy, Aspergillosis
Pubmed
Web of science
Création de la notice
02/01/2015 10:27
Dernière modification de la notice
20/08/2019 16:13
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