The Role of Nutrition in the Treatment of Sarcopenia in Old Patients: From Restoration of Mitochondrial Activity to Improvement of Muscle Performance, a Systematic Review.
Détails
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_A8AF5C79D6C7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The Role of Nutrition in the Treatment of Sarcopenia in Old Patients: From Restoration of Mitochondrial Activity to Improvement of Muscle Performance, a Systematic Review.
Périodique
Nutrients
ISSN
2072-6643 (Electronic)
ISSN-L
2072-6643
Statut éditorial
Publié
Date de publication
24/08/2023
Peer-reviewed
Oui
Volume
15
Numéro
17
Langue
anglais
Notes
Publication types: Systematic Review ; Journal Article ; Review
Publication Status: epublish
Publication Status: epublish
Résumé
Sarcopenia is an age-related disease characterized by loss of muscle strength, mass and performance. Malnutrition contributes to sarcopenia pathogenesis. The aim of this systematic review is to analyze existing evidence on the efficacy of nutritional supplementation on muscle and mitochondrial health among sarcopenic or malnourished older adults. We included randomized controlled trials (RCTs) assessing the effect of branched-chain amino acid (BCAA), vitamin D and/or omega-3 polyunsaturated fatty acid (PUFA) on muscle mass, strength and performance and/or on mitochondrial activity and redox state in older sarcopenic and/or malnourished adults. The literature search was on MEDLINE, Embase and Cochrane Central, restricted to articles published in the last 10 years (2012-2022). Twelve RCTs with a total of 1337 subjects were included. BCAA with vitamin D significantly ameliorates appendicular muscle mass (4 RCTs), hand grip strength (4 RCTs), gait speed (3 RCTs), short physical performance battery (3 RCTs) or chair stand test (3 RCTs) among six out of nine RCTs. BCAA alone (2 RCTs) or PUFA (1 RCT) were not effective in improving muscle health. Mitochondrial function was significantly improved by the administration of BCAA alone (1 RCT) or in association with vitamin D (1 RCT). In conclusion, BCAA in association with vitamin D may be useful in the treatment of sarcopenia and boost mitochondrial bioenergetic and redox activity. PROSPERO CRD42022332288.
Mots-clé
Humans, Aged, Sarcopenia/therapy, Muscles, Nutritional Status, Malnutrition, Vitamin D/therapeutic use, Vitamins, Amino Acids, Branched-Chain/therapeutic use, Mitochondria, BCAA, geriatrics, malnutrition, mitochondrial bioenergetic, older adults, omega-3 PUFA, redox activity, sarcopenia, vitamin D
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/09/2023 11:36
Dernière modification de la notice
08/08/2024 7:27