On the relationship between free plasma and saliva amitriptyline and nortriptyline.

Détails

ID Serval
serval:BIB_A896755FC0CD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
On the relationship between free plasma and saliva amitriptyline and nortriptyline.
Périodique
International pharmacopsychiatry
Auteur⸱e⸱s
Baumann P., Tinguely D., Koeb L., Schöpf J., Le P.K.
ISSN
0020-8272 (Print)
ISSN-L
0020-8272
Statut éditorial
Publié
Date de publication
1982
Peer-reviewed
Oui
Volume
17
Numéro
3
Pages
136-146
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Résumé
Conflicting results on the correlation of tricyclic levels in plasma and saliva have raised doubts about the clinical usefulness of monitoring these drugs in the latter body fluid. However, saliva drug levels may reflect the free plasma concentration, which possibly determines its level in the brain. In two groups of depressive patients, the evolution was studied of the levels of amitriptyline and nortriptyline in plasma (as free and total) and in saliva, after the administration of amitriptyline. The results show a poor correlation between total plasma and saliva concentration of amitriptyline and nortriptyline, respectively. Levels of both tricyclics in saliva exceed by far those measured in plasma dialysate. However, the relationship is such that free plasma concentrations may be predicted from those measured in saliva, if one takes into account saliva pH at the moment of collecting the sample.
Mots-clé
Amitriptyline/blood, Amitriptyline/metabolism, Depressive Disorder/metabolism, Humans, Hydrogen-Ion Concentration, Nortriptyline/blood, Nortriptyline/metabolism, Saliva/metabolism, Time Factors
Pubmed
Web of science
Création de la notice
11/01/2021 12:34
Dernière modification de la notice
15/04/2023 6:51
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