Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.

Détails

ID Serval
serval:BIB_A88A90750A2B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.
Périodique
Nature Immunology
Auteur(s)
Karkkainen M.J., Haiko P., Sainio K., Partanen J., Taipale J., Petrova T.V., Jeltsch M., Jackson D.G., Talikka M., Rauvala H., Betsholtz C., Alitalo K.
ISSN
1529-2908 (Print)
ISSN-L
1529-2908
Statut éditorial
Publié
Date de publication
2004
Volume
5
Numéro
1
Pages
74-80
Langue
anglais
Résumé
Lymphatic vessels are essential for immune surveillance, tissue fluid homeostasis and fat absorption. Defects in lymphatic vessel formation or function cause lymphedema. Here we show that the vascular endothelial growth factor C (VEGF-C) is required for the initial steps in lymphatic development. In Vegfc-/- mice, endothelial cells commit to the lymphatic lineage but do not sprout to form lymph vessels. Sprouting was rescued by VEGF-C and VEGF-D but not by VEGF, indicating VEGF receptor 3 specificity. The lack of lymphatic vessels resulted in prenatal death due to fluid accumulation in tissues, and Vegfc+/- mice developed cutaneous lymphatic hypoplasia and lymphedema. Our results indicate that VEGF-C is the paracrine factor essential for lymphangiogenesis, and show that both Vegfc alleles are required for normal lymphatic development.
Mots-clé
Animals, Embryonic and Fetal Development/genetics, Embryonic and Fetal Development/physiology, Female, Immunohistochemistry, Lymphangiogenesis/genetics, Lymphangiogenesis/physiology, Lymphatic Vessels/embryology, Lymphedema/physiopathology, Male, Mice, Mice, Inbred ICR, Mice, Knockout, Microscopy, Fluorescence, Receptors, Vascular Endothelial Growth Factor/physiology, Vascular Endothelial Growth Factor C/deficiency, Vascular Endothelial Growth Factor C/genetics, Vascular Endothelial Growth Factor Receptor-3/genetics, Vascular Endothelial Growth Factor Receptor-3/physiology
Pubmed
Web of science
Création de la notice
20/12/2012 15:48
Dernière modification de la notice
20/08/2019 15:13
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