Expression of homeobox-containing genes in primary and metastatic colorectal cancer

Détails

ID Serval
serval:BIB_A86262CBCC5A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Expression of homeobox-containing genes in primary and metastatic colorectal cancer
Périodique
European Journal of Cancer
Auteur(s)
De Vita  G., Barba  P., Odartchenko  N., Givel  J. C., Freschi  G., Bucciarelli  G., Magli  M. C., Boncinelli  E., Cillo  C.
ISSN
0959-8049 (Print)
Statut éditorial
Publié
Date de publication
1993
Volume
29A
Numéro
6
Pages
887-93
Notes
Journal Article
Research Support, Non-U.S. Gov't
Résumé
Homeobox genes are a network of genes encoding nuclear proteins functioning as transcriptional regulators. Human and murine homeobox genes of the HOX family are organised in four clusters on different chromosomes. Gene order within each cluster is highly conserved, perhaps in direct relation to their expression. Homeobox genes have recently been involved in normal development and oncogenesis. We have analysed HOX gene expression in normal human colon and in primary and metastatic colorectal carcinomas. The majority of HOX genes are active in normal adult colon and their overall expression pattern is characteristic of this organ. Furthermore, the expression of some HOX genes is identical in normal and neoplastic colon indicating that these genes may exert an organ-specific function. In contrast, other HOX genes exhibit altered expression in primary colon cancers and their hepatic metastases which may suggest an association with colon cancer progression.
Mots-clé
Colon/chemistry Colorectal Neoplasms/*genetics Gene Expression Regulation, Neoplastic *Genes, Homeobox Humans Intestinal Mucosa/chemistry Liver Neoplasms/genetics/secondary
Pubmed
Web of science
Création de la notice
28/01/2008 9:56
Dernière modification de la notice
20/08/2019 16:12
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