Catecholamines and their O-methylated metabolites in vitreous humor in hypothermia cases.

Détails

ID Serval
serval:BIB_A8571DCFC46B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Catecholamines and their O-methylated metabolites in vitreous humor in hypothermia cases.
Périodique
Forensic science, medicine, and pathology
Auteur(s)
Hervet T., Teresiński G., Hejna P., Descloux E., Grouzmann E., Palmiere C.
ISSN
1556-2891 (Electronic)
ISSN-L
1547-769X
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
12
Numéro
2
Pages
163-169
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
PURPOSE: The aim of this study was to assess the diagnostic value of catecholamines and their O-methylated metabolites in vitreous humor samples in identifying antemortem cold exposure and fatal hypothermia in the forensic casework.
METHODS: A total of 80 autopsy cases (40 hypothermia fatalities and 40 cases in which hypothermia as the main or contributory cause of death was excluded) were selected for this study. Catecholamines and their O-methylated metabolites were measured in urine and vitreous humor samples collected at autopsy.
RESULTS: Urine catecholamine and their O-methylated metabolite concentrations were significantly higher in hypothermia-related deaths. On the other hand, measurements in vitreous humor samples did not reveal statistically significant differences between hypothermia-related deaths and controls.
CONCLUSIONS: Globally considered, our findings seem to suggest that, contrary to urine catecholamines and their O-methylated metabolites, vitreous levels of these compounds appear to be of limited value in characterizing human antemortem stress reactions due to cold exposure and can hardly be used in the forensic setting to support the diagnosis of hypothermia.
Pubmed
Web of science
Création de la notice
31/03/2016 14:12
Dernière modification de la notice
20/08/2019 16:12
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