euHCVdb: the European hepatitis C virus database

Détails

ID Serval
serval:BIB_A853DA750B54
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
euHCVdb: the European hepatitis C virus database
Périodique
Nucleic Acids Research
Auteur(s)
Combet  C., Garnier  N., Charavay  C., Grando  D., Crisan  D., Lopez  J., Dehne-Garcia  A., Geourjon  C., Bettler  E., Hulo  C., Le Mercier  P., Bartenschlager  R., Diepolder  H., Moradpour  D., Pawlotsky  J. M., Rice  C. M., Trepo  C., Penin  F., Deleage  G.
ISSN
1362-4962 (Electronic)
Statut éditorial
Publié
Date de publication
01/2007
Volume
35
Numéro
Database issue
Pages
D363-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Résumé
The hepatitis C virus (HCV) genome shows remarkable sequence variability, leading to the classification of at least six major genotypes, numerous subtypes and a myriad of quasispecies within a given host. A database allowing researchers to investigate the genetic and structural variability of all available HCV sequences is an essential tool for studies on the molecular virology and pathogenesis of hepatitis C as well as drug design and vaccine development. We describe here the European Hepatitis C Virus Database (euHCVdb, http://euhcvdb.ibcp.fr), a collection of computer-annotated sequences based on reference genomes. The annotations include genome mapping of sequences, use of recommended nomenclature, subtyping as well as three-dimensional (3D) molecular models of proteins. A WWW interface has been developed to facilitate database searches and the export of data for sequence and structure analyses. As part of an international collaborative effort with the US and Japanese databases, the European HCV Database (euHCVdb) is mainly dedicated to HCV protein sequences, 3D structures and functional analyses.
Mots-clé
*Databases, Protein Genome, Viral Genomics Hepacivirus/*genetics Internet Models, Molecular Protein Conformation Sequence Analysis, Protein User-Computer Interface Viral Proteins/*chemistry/*genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 17:06
Dernière modification de la notice
20/08/2019 16:12
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