Lack of correlation between serum titres of interferon alpha, beta, natural killer cell activity and clinical susceptibility in mice infected with two isolates of lymphocytic choriomeningitis virus.

Détails

ID Serval
serval:BIB_A84E49130417
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Lack of correlation between serum titres of interferon alpha, beta, natural killer cell activity and clinical susceptibility in mice infected with two isolates of lymphocytic choriomeningitis virus.
Périodique
Journal of General Virology
Auteur(s)
Leist T.P., Aguet M., Hässig M., Pevear D.C., Pfau C.J., Zinkernagel R.M.
ISSN
0022-1317 (Print)
ISSN-L
0022-1317
Statut éditorial
Publié
Date de publication
1987
Volume
68
Numéro
8
Pages
2213-2218
Langue
anglais
Résumé
Intracerebral infection of adult immunocompetent mice with most strains of lymphocytic choriomeningitis virus (LCMV) caused a systemic infection and led to severe meningoencephalitis and death due to the induced T cell immune response. The susceptibility of congenic mice to the two plaque variants Docile and Aggressive of LCMV strain UBC was shown to be mouse strain-dependent. To investigate the possible correlation between acid-stable interferon (IFN) and natural killer (NK) cell responses and the susceptibility to the two UBC LCMV substrains, serum titres of acid-stable antiviral activity, presumably IFN-alpha, beta and NK cell activities were determined in various mouse strains at different times after intracerebral infection. The two viral isolates induced comparable IFN-alpha, beta serum titres and caused similar NK activities in the same mouse strain. Between different mouse strains, marked differences in the kinetics and amount of IFN production were observed, yet there was no correlation with the susceptibility to the two UBC LCMV substrains. Additionally, there was no correlation between the magnitude of the IFN-alpha, beta serum titres and the NK activities induced in the spleen by the viral inocula. Overall, the findings suggest that levels of circulating IFN-alpha, beta are only of minor importance for the development of LCM disease.
Mots-clé
Animals, Disease Susceptibility, Female, Interferon Type I/blood, Killer Cells, Natural/immunology, Kinetics, Lymphocytic Choriomeningitis/blood, Lymphocytic Choriomeningitis/immunology, Lymphocytic choriomeningitis virus/immunology, Lymphocytic choriomeningitis virus/pathogenicity, Male, Mice, Mice, Inbred Strains, Species Specificity
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:36
Dernière modification de la notice
20/08/2019 16:12
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