Nature of changes in adrenocortical function in chronic hyperleptinemic female rats

Détails

ID Serval
serval:BIB_A84D7C6BA910
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Nature of changes in adrenocortical function in chronic hyperleptinemic female rats
Périodique
Endocrine
Auteur(s)
Perello  M., Moreno  G., Camihort  G., Luna  G., Console  G., Gaillard  R. C., Spinedi  E.
ISSN
0969-711X (Print)
Statut éditorial
Publié
Date de publication
07/2004
Volume
24
Numéro
2
Pages
167-75
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
Neonatal treatment of rats with monosodium L-glutamate, which destroys hypothalamic arcuate nucleus neuronal bodies, induces several metabolic abnormalities; as a result, rats develop a phenotype of pseudoobesity. This study was designed to explore, in the monosodium L-glutamate-treated female rat, the influence of chronic hyperleptinemia on adrenal cortex functionality. For this purpose, we evaluated in control and hypothalamic-damaged rats: (a) in vivo and in vitro adrenocortical function, (b) adrenal leptin receptor immunodistribution and mRNA expression, and (c) whether the inhibitory effect of leptin on adrenal function remains. Our results indicate that, compared to normal counterparts, pseudoobese animals displayed (1) hyperadiposity, despite being hypophagic and of lower body weight, (2) in vivo and in vitro enhanced adrenocortical response to ACTH stimulation, (3) an in vitro adrenal fasciculata-reticularis cell hyper-sensitivity to ACTH stimulus, (4) hyperplasia of their adrenal zona fasciculata cells, and (5) adrenal fasciculata-reticularis cell refractoriness to the inhibitory effect of leptin on ACTH-stimulated glucocorticoid production due, at least in part, to decreased adrenal leptin receptor expression. These data further support that increased hypothalamo-pituitary-adrenal axis function, in the adult neurotoxin-lesioned female rat, is mainly dependent on the development of both hyperplasia of adrenal zona fasciculata and adrenal gland refractoriness to leptin inhibitory effect. Our study supports that adrenal leptin resistance could be responsible, at least in part, for enhanced glucocorticoid circulating levels in this phenotype of obesity.
Mots-clé
Adrenal Cortex/chemistry/drug effects/*physiopathology Adrenal Glands/chemistry/drug effects/physiopathology Adrenocorticotropic Hormone/pharmacology Animals Animals, Newborn Arcuate Nucleus/drug effects Drug Resistance Female Glucocorticoids/biosynthesis/blood Hyperplasia Hypothalamic Diseases/chemically induced/physiopathology Leptin/*blood/pharmacology Obesity/etiology RNA, Messenger/analysis Rats Receptors, Cell Surface/analysis/genetics Sodium Glutamate/administration & dosage Zona Fasciculata/drug effects/pathology/physiopathology
Pubmed
Web of science
Création de la notice
15/02/2008 16:58
Dernière modification de la notice
20/08/2019 15:12
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