Single cell gene expression profiling reveals qualitatively distinct CD8 T cells elicited by different gene-based vaccines
Détails
ID Serval
serval:BIB_A83A53047AEB
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Single cell gene expression profiling reveals qualitatively distinct CD8 T cells elicited by different gene-based vaccines
Titre de la conférence
Annual Congress SGAI-SSAI, Advances in immunology and allergology: from research to diagnosis and therapy
Adresse
Lugano, Switzerland, March 17-18, 2011
ISBN
0344-5062
Statut éditorial
Publié
Date de publication
2011
Volume
34
Série
Allergologie
Pages
81-81
Langue
anglais
Notes
Meeting Abstract
Résumé
The CD8 T cell response generatedby gene-based vaccines is importantfor protective immunity againstmany infectious diseases but its complexityis incompletely understood.Here, we report that different vaccinesencoding HIV Env elicit qualitativelydistinct CD8 T cells that wereidentified by patterns of gene expressionin individual cells. Three alternativeprime-boost vector combinationsstimulated antigen-specific CD8 Tcell populations of similar magnitudeand function by intracellular cytokinestaining; however, single cell geneexpression profiling enabled the discriminationof distinct CM and EMCD8 cells elicited by the three vaccines.Two previously unrecognizedCD8 T cell subsets have been definedby their coexpression of Eomes,Cxcr3 and Ccr7; or Klrk1, Klrg1 andCcr5 in CM and EM cells respectively.
Web of science
Création de la notice
04/04/2011 10:48
Dernière modification de la notice
20/08/2019 15:12