Accelerated decline in lung function in smoking women with airway obstruction: SAPALDIA 2 cohort study

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_A8285DBCD54D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Accelerated decline in lung function in smoking women with airway obstruction: SAPALDIA 2 cohort study
Périodique
Respiratory Research
Auteur(s)
Downs  S. H., Brandli  O., Zellweger  J. P., Schindler  C., Kunzli  N., Gerbase  M. W., Burdet  L., Bettschart  R., Zemp  E., Frey  M., Keller  R., Tschopp  J. M., Leuenberger  P., Ackermann-Liebrich  U.
ISSN
1465-993X (Electronic)
Statut éditorial
Publié
Date de publication
2005
Volume
6
Pages
45
Notes
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Résumé
BACKGROUND: The aim was to determine if effects from smoking on lung function measured over 11 years differ between men and women. METHODS: In a prospective population based cohort study (Swiss Study on Air Pollution and Lung Diseases in Adults) current smokers in 1991 (18-60 yrs) were reassessed in 2002 (n = 1792). Multiple linear regression was used to estimate effects from pack-years of cigarettes smoked to 1991 and mean packs of cigarettes smoked per day between 1991 and 2002 on change in lung volume and flows over the 11 years. RESULTS: In both sexes, packs smoked between assessments were related to lung function decline but pack-years smoked before 1991 were not. Mean annual decline in FEV1 was -10.4 mL(95%CI -15.3, -5.5) per pack per day between assessments in men and -13.8 mL(95%CI-19.5,-8.1) in women. Decline per pack per day between 1991 and 2002 was lower in women who smoked in 1991 but quit before 2002 compared to persistent smokers (-6.4 vs -11.6 mL, p = 0.05) but this was not seen in men (-14.3 vs -8.8 mL p = 0.49). Smoking related decline was accelerated in men and women with airway obstruction, particularly in women where decline in FEV1 was three fold higher in participants with FEV1/FVC<0.70 compared to other women (-39.4 vs -12.2 mL/yr per pack per day, p < 0.002). CONCLUSION: There are differences in effects from smoking on lung function between men and women. Lung function recovers faster in women quitters than in men. Women current smokers with airway obstruction experience a greater smoking related decline in lung function than men.
Mots-clé
Adolescent Adult Airway Obstruction/*diagnosis/*epidemiology Cohort Studies Comorbidity Disease Progression Female Humans Incidence Male Middle Aged Prognosis *Recovery of Function Respiratory Function Tests/*statistics & numerical data Risk Assessment/*methods Risk Factors Smoking/*epidemiology Switzerland/epidemiology Tidal Volume Time Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 9:49
Dernière modification de la notice
20/08/2019 15:12
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