Exaggerated pulmonary hypertension during mild exercise in chronic mountain sickness.

Détails

ID Serval
serval:BIB_A7FD6C367591
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Exaggerated pulmonary hypertension during mild exercise in chronic mountain sickness.
Périodique
Chest
Auteur(s)
Stuber Thomas, Sartori Claudio, Schwab Marcos, Jayet Pierre-Yves, Rimoldi Stefano F., Garcin Sophie, Thalmann Sebastien, Spielvogel Hilde, Salinas Salmon Carlos, Villena Mercedes, Scherrer Urs, Allemann Yves
ISSN
1931-3543[electronic], 0012-3692[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
137
Numéro
2
Pages
388-392
Langue
anglais
Résumé
BACKGROUND: Chronic mountain sickness (CMS) is an important public health problem and is characterized by exaggerated hypoxemia, erythrocytosis, and pulmonary hypertension. While pulmonary hypertension is a leading cause of morbidity and mortality in patients with CMS, it is relatively mild and its underlying mechanisms are not known. We speculated that during mild exercise associated with daily activities, pulmonary hypertension in CMS is much more pronounced. METHODS: We estimated pulmonary artery pressure by using echocardiography at rest and during mild bicycle exercise at 50 W in 30 male patients with CMS and 32 age-matched, healthy control subjects who were born and living at an altitude of 3,600 m. RESULTS: The modest, albeit significant difference of the systolic right-ventricular-to-right-atrial pressure gradient between patients with CMS and controls at rest (30.3 +/- 8.0 vs 25.4 +/- 4.5 mm Hg, P 5 .002) became more than three times larger during mild bicycle exercise (56.4 +/- 19.0 vs 39.8 +/- 8.0 mm Hg, P < .001). CONCLUSIONS: Measurements of pulmonary artery pressure at rest greatly underestimate pulmonary artery pressure during daily activity in patients with CMS. The marked pulmonary hypertension during mild exercise associated with daily activity may explain why this problem is a leading cause of morbidity and mortality in patients with CMS.
Mots-clé
Enhanced Doppler-Echocardiography, High-Altitude, Artery Pressure, Noninvasive Evaluation, Hypoxia, Disease
Pubmed
Web of science
Création de la notice
09/03/2010 14:54
Dernière modification de la notice
20/08/2019 16:12
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