Low-pass DNA sequencing of 1200 Sardinians reconstructs European Y-chromosome phylogeny.
Détails
ID Serval
serval:BIB_A7990B130979
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Low-pass DNA sequencing of 1200 Sardinians reconstructs European Y-chromosome phylogeny.
Périodique
Science
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
02/08/2013
Peer-reviewed
Oui
Volume
341
Numéro
6145
Pages
565-569
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Genetic variation within the male-specific portion of the Y chromosome (MSY) can clarify the origins of contemporary populations, but previous studies were hampered by partial genetic information. Population sequencing of 1204 Sardinian males identified 11,763 MSY single-nucleotide polymorphisms, 6751 of which have not previously been observed. We constructed a MSY phylogenetic tree containing all main haplogroups found in Europe, along with many Sardinian-specific lineage clusters within each haplogroup. The tree was calibrated with archaeological data from the initial expansion of the Sardinian population ~7700 years ago. The ages of nodes highlight different genetic strata in Sardinia and reveal the presumptive timing of coalescence with other human populations. We calculate a putative age for coalescence of ~180,000 to 200,000 years ago, which is consistent with previous mitochondrial DNA-based estimates.
Mots-clé
Adult, Chromosomes, Human, Y/classification, Chromosomes, Human, Y/genetics, European Continental Ancestry Group/genetics, Evolution, Molecular, Haplotypes, Humans, Italy, Male, Phylogeny, Polymorphism, Single Nucleotide
Pubmed
Web of science
Création de la notice
18/01/2021 22:42
Dernière modification de la notice
19/01/2021 7:26