Bile acids and their signaling pathways: eclectic regulators of diverse cellular functions.

Détails

ID Serval
serval:BIB_A785A74DE0DF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Bile acids and their signaling pathways: eclectic regulators of diverse cellular functions.
Périodique
Cellular and molecular life sciences
Auteur⸱e⸱s
Scotti E., Gilardi F., Godio C., Gers E., Krneta J., Mitro N., De Fabiani E., Caruso D., Crestani M.
ISSN
1420-682X (Print)
ISSN-L
1420-682X
Statut éditorial
Publié
Date de publication
10/2007
Peer-reviewed
Oui
Volume
64
Numéro
19-20
Pages
2477-2491
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
The field of bile acids has witnessed an impulse in the last two decades. This has been the result of cloning the genes encoding enzymes of bile acid synthesis and their transporters. There is no doubt that the identification of Farnesoid X Receptor (FXR, NR1H4) as the bile acid receptor has contributed substantially to attract the interest of scientists in this area. When FXR was cloned by Forman et al. [1], farnesol metabolites were initially considered the physiological ligands. After identifying FXR and other nuclear receptors as bile acid sensors [2-4], it has become clear that bile acids are involved in the regulation of lipid and glucose metabolism and that these molecules are eclectic regulators of diverse cellular functions. In this review, we will summarize the current knowledge of the functions regulated by bile acids and how their physiological receptors mediate the signaling underlying numerous cellular responses.
Mots-clé
Bile Acids and Salts, DNA-Binding Proteins/metabolism, Glucose/metabolism, Humans, Lipid Metabolism, Receptors, Cytoplasmic and Nuclear/metabolism, Signal Transduction, Transcription Factors/metabolism
Pubmed
Web of science
Création de la notice
21/03/2019 11:29
Dernière modification de la notice
20/02/2020 6:26
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