The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.

Détails

ID Serval
serval:BIB_A76D5C40117C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.
Périodique
Nature immunology
Auteur(s)
Castro W., Chelbi S.T., Niogret C., Ramon-Barros C., Welten SPM, Osterheld K., Wang H., Rota G., Morgado L., Vivier E., Raeber M.E., Boyman O., Delorenzi M., Barras D., Ho P.C., Oxenius A., Guarda G.
ISSN
1529-2916 (Electronic)
ISSN-L
1529-2908
Statut éditorial
Publié
Date de publication
08/2018
Peer-reviewed
Oui
Volume
19
Numéro
8
Pages
809-820
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Regulatory factor X 7 (Rfx7) is an uncharacterized transcription factor belonging to a family involved in ciliogenesis and immunity. Here, we found that deletion of Rfx7 leads to a decrease in natural killer (NK) cell maintenance and immunity in vivo. Genomic approaches showed that Rfx7 coordinated a transcriptional network controlling cell metabolism. Rfx7 <sup>-/-</sup> NK lymphocytes presented increased size, granularity, proliferation, and energetic state, whereas genetic reduction of mTOR activity mitigated those defects. Notably, Rfx7-deficient NK lymphocytes were rescued by interleukin 15 through engagement of the Janus kinase (Jak) pathway, thus revealing the importance of this signaling for maintenance of such spontaneously activated NK cells. Rfx7 therefore emerges as a novel transcriptional regulator of NK cell homeostasis and metabolic quiescence.
Mots-clé
Animals, Cell Proliferation, Cell Survival, Cells, Cultured, Chimera, Energy Metabolism, Gene Regulatory Networks, Immunity, Cellular/genetics, Immunity, Innate/genetics, Interleukin-15/metabolism, Janus Kinases/metabolism, Killer Cells, Natural/immunology, Killer Cells, Natural/metabolism, Mice, Mice, Inbred C57BL, Mice, Knockout, Regulatory Factor X1/genetics, Regulatory Factor X1/metabolism, Signal Transduction, TOR Serine-Threonine Kinases/genetics, TOR Serine-Threonine Kinases/metabolism
Pubmed
Web of science
Création de la notice
18/07/2018 17:08
Dernière modification de la notice
20/08/2019 16:12
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