Specific tolerization of active cytolytic T lymphocyte responses in vivo with soluble peptides

Détails

ID Serval
serval:BIB_A7383A0BF272
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Specific tolerization of active cytolytic T lymphocyte responses in vivo with soluble peptides
Périodique
Cellular Immunology
Auteur(s)
Duarte  E. A., Eberl  G., Corradin  G.
ISSN
0008-8749 (Print)
Statut éditorial
Publié
Date de publication
04/1996
Volume
169
Numéro
1
Pages
16-23
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr 10
Résumé
A promising approach toward preventing and treating autoimmune disease involves identifying the mediating antigen and then tolerizing the autoreactive T cells with the corresponding antigen. For success, this method will require the specific tolerization of active helper or CTL responses while maintaining the integrity of the immune system. In this report, we selectively eliminated an ongoing CTL response by administering soluble peptide. BALB/c mice were immunized with two H-2Kd-restricted immunodominant CTL epitopes derived from HIV and malaria together with a T helper epitope to elicit a strong CTL response. Beginning 3 days later, mice were injected 3 times at 3-day intervals with 500 micrograms of only one or both of these epitopes in PBS. Following these injections, only one of two active CTL responses was tolerized without affecting T helper cells. This tolerization state requires antigen for its maintenance, may be retolerized upon return, and is not due to active or antigen-driven bystander suppression. This study suggests that soluble peptides may be utilized to treat or prevent autoimmune diseases caused by autoreactive CTLs.
Mots-clé
Amino Acid Sequence Animals Female HIV/immunology Immunodominant Epitopes/immunology Lymphocyte Activation/*drug effects Mice Mice, Inbred BALB C Molecular Sequence Data Peptides/*pharmacology T-Lymphocytes, Cytotoxic/*immunology
Pubmed
Web of science
Création de la notice
24/01/2008 14:55
Dernière modification de la notice
20/08/2019 15:12
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