Acidose lactique et hyperlactatemie. [Lactic acidosis and hyperlactatemia]

Détails

ID Serval
serval:BIB_A731F4B46948
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Acidose lactique et hyperlactatemie. [Lactic acidosis and hyperlactatemia]
Périodique
Revue du Praticien
Auteur⸱e⸱s
Potin  M., Perret  C.
ISSN
0035-2640 (Print)
Statut éditorial
Publié
Date de publication
10/1990
Volume
40
Numéro
22
Pages
2042-6
Notes
English Abstract
Journal Article --- Old month value: Oct 1
Résumé
Lactic acidosis is a relatively frequent acid-base disorder in a hospital setting. It is defined by the association of an arterial pH inferior to 7.35 and an arterial lactate level superior to 5 mmol/l. Classically, 2 types of acidosis are distinguished on the basis of their mechanisms of onset: the type A, with evident clinical signs of tissue hypoperfusion and the type B, more are, without apparent hypoxia. This last category is observed in various circumstances such as diabetes, acute liver failure, poisoning and, more rarely, inborn errors of carbohydrate metabolism. Treatment aims primarily at the correction of the cause. The efficacy of sodium bicarbonate is presently debated, considering the risk to worsen hyperlactatemia and to induce hyperosmolarity or rebound alkalosis. The administration of dichloroacetate, an activator of pyruvate dehydrogenase, permits to correct partially the lactic acidosis but is not harmless especially in case of prolonged administration. Other therapeutic modalities are evoked. Arterial lactate level is a reliable prognostic index of shock, because blood values do not depend only of the oxygen debt but also of the efficacy of hepatic and renal lactate uptake. Sequential measurements are recommended.
Mots-clé
*Acidosis, Lactic/classification/drug therapy/metabolism Bicarbonates/therapeutic use Dichloroacetate/therapeutic use Humans Lactates/*blood/metabolism
Pubmed
Création de la notice
24/01/2008 21:10
Dernière modification de la notice
20/08/2019 16:12
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