DQ beta polymorphism and genetic susceptibility to Felty's syndrome

Détails

ID Serval
serval:BIB_A70F20E656B9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
DQ beta polymorphism and genetic susceptibility to Felty's syndrome
Périodique
Arthritis and Rheumatism
Auteur⸱e⸱s
So  A. K., Warner  C. A., Sansom  D., Walport  M. J.
ISSN
0004-3591 (Print)
Statut éditorial
Publié
Date de publication
08/1988
Volume
31
Numéro
8
Pages
990-4
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Résumé
We used an oligonucleotide probe specific for a polymorphic sequence in the HLA-DQ beta gene to investigate the role of DQ polymorphism in genetic susceptibility to Felty's syndrome (FS) and rheumatoid arthritis (RA). The sequence of this gene was identified from a complementary DNA library derived from an RA patient's B lymphoblastoid cell line. With this probe, we studied the prevalence of the specific DQ beta allele in DR4 positive FS patients, RA patients, and normal control subjects. Significantly more FS patients (17 of 25) showed hybridization with this oligonucleotide probe, compared with the number of DR4 positive non-FS RA patients (7 of 23) and normal controls (7 of 21). The findings indicate that genes linked to the DQ region are important in determining susceptibility to FS.
Mots-clé
Arthritis, Rheumatoid/*genetics Disease Susceptibility Felty's Syndrome/*genetics HLA-D Antigens/*genetics HLA-DQ Antigens/*genetics HLA-DR Antigens/genetics HLA-DR4 Antigen Haplotypes Humans Nucleic Acid Hybridization Oligonucleotides *Polymorphism, Genetic
Pubmed
Web of science
Création de la notice
25/01/2008 9:39
Dernière modification de la notice
20/08/2019 16:11
Données d'usage