NLRC5, at the Heart of Antigen Presentation.

Détails

Ressource 1Télécharger: BIB_A6E6402ADB87.P001.pdf (1767.21 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_A6E6402ADB87
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
NLRC5, at the Heart of Antigen Presentation.
Périodique
Frontiers in Immunology
Auteur(s)
Neerincx A., Castro W., Guarda G., Kufer T.A.
ISSN
1664-3224 (Print)
ISSN-L
1664-3224
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
4
Pages
397
Langue
anglais
Résumé
Nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs) are intracellular proteins mainly involved in pathogen recognition, inflammatory responses, and cell death. Until recently, the function of the family member NLR caspase recruitment domain (CARD) containing 5 (NLRC5) has been a matter of debate. It is now clear that NLRC5 acts as a transcriptional regulator of the major-histocompatibility complex class I. In this review we detail the development of our understanding of NLRC5 function, discussing both the accepted and the controversial aspects of NLRC5 activity. We give insight into the molecular mechanisms, and the potential implications, of NLRC5 function in health and disease.
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/12/2013 17:44
Dernière modification de la notice
20/08/2019 16:11
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