Cardiomyocyte Lineage Specification in Adult Human Cardiac Precursor Cells Via Modulation of Enhancer-Associated Long Noncoding RNA Expression.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_A6AFB5D6ECD9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cardiomyocyte Lineage Specification in Adult Human Cardiac Precursor Cells Via Modulation of Enhancer-Associated Long Noncoding RNA Expression.
Périodique
JACC. Basic to translational science
Auteur⸱e⸱s
Plaisance I., Perruchoud S., Fernandez-Tenorio M., Gonzales C., Ounzain S., Ruchat P., Nemir M., Niggli E., Pedrazzini T.
ISSN
2452-302X (Electronic)
ISSN-L
2452-302X
Statut éditorial
Publié
Date de publication
10/2016
Peer-reviewed
Oui
Volume
1
Numéro
6
Pages
472-493
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The mechanisms controlling differentiation in adult cardiac precursor cells (CPCs) are still largely unknown. In this study, CPCs isolated from the human heart were found to produce predominantly smooth muscle cells but could be redirected to the cardiomyocyte fate by transient activation followed by inhibition of NOTCH signaling. NOTCH inhibition repressed <i>MIR-143/145</i> expression, and blocked smooth muscle differentiation. Expression of the microRNAs is under control of <i>CARMEN</i> , a long noncoding RNA associated with an enhancer located in the <i>MIR-143/145</i> locus and target of NOTCH signaling. The <i>CARMEN</i> / <i>MIR-145/143</i> axis represents, therefore, a promising target to favor production of cardiomyocytes in cell replacement therapies.
Mots-clé
NOTCH, cardiac precursor cells, differentiation, heart disease, lncRNAs, miRNAs
Pubmed
Open Access
Oui
Création de la notice
04/09/2018 8:55
Dernière modification de la notice
20/08/2019 16:11
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