Effects of chronic NO synthase inhibition in rats on renin-angiotensin system and sympathetic nervous system.

Détails

ID Serval
serval:BIB_A69E70D80300
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of chronic NO synthase inhibition in rats on renin-angiotensin system and sympathetic nervous system.
Périodique
American Journal of Physiology. Heart and Circulatory Physiology
Auteur(s)
Zanchi A., Schaad N.C., Osterheld M.C., Grouzmann E., Nussberger J., Brunner H.R., Waeber B.
ISSN
0363-6135
ISSN-L
0363-6135
Statut éditorial
Publié
Date de publication
06/1995
Volume
268
Numéro
6 Pt 2
Pages
H2267-H2273
Langue
anglais
Résumé
This study was designed to assess the role of renin and of the sympathoadrenal system in the maintenance of the hypertension induced by chronic nitric oxide synthase (NOS) inhibition in rats kept on a normal (RS) or a low-sodium (LS) diet. With the administration of NG-nitro-L-arginine methyl ester (L-NAME) in drinking water (0.4 milligrams) for 6 wk, mean intra-arterial blood pressure rose to a similar extent to 201 mmHg in the RS and 184 mmHg in the LS animals. Simultaneously, plasma norepinephrine was increased to 838 and 527 pg/ml and epinephrine to 2,041 and 1,341 pg/ml in RS and LS, respectively. Plasma neuropeptide Y levels did not change. Plasma renin activity rose to 21 ng.ml-1.h-1 in RS but remained at 44 ng.ml-1.h-1 in the LS. Both losartan (10 mg/kg) and phentolamine (0.1 mg/kg) intravenous bolus injections reduced blood pressure considerably in the L-NAME hypertensive animals. Whole brain NOS activity was reduced by 84%. Hypertension induced by chronic NOS inhibition in LS as well as in RS fed rats seems to be sustained by an interaction of several mechanisms, including the activation of the sympathetic nervous system and the renin-angiotensin system.
Mots-clé
Amino Acid Oxidoreductases, Analysis of Variance, Animals, Antihypertensive Agents, Arginine, Biphenyl Compounds, Blood Pressure, Brain, Creatinine, Diet, Sodium-Restricted, Epinephrine, Heart Rate, Hypertension, Imidazoles, Kidney, Losartan, Male, NG-Nitroarginine Methyl Ester, Neuropeptide Y, Nitric Oxide Synthase, Norepinephrine, Phentolamine, Rats, Rats, Wistar, Reference Values, Renin, Renin-Angiotensin System, Sympathetic Nervous System, Tetrazoles, Weight Gain
Pubmed
Création de la notice
25/01/2008 11:55
Dernière modification de la notice
20/08/2019 16:11
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