Antiretinale Antikorper assoziiert mit zystoidem Makulaodem. [Antiretinal antibodies associated with cystoid macular edema]

Détails

ID Serval
serval:BIB_A64EB4972D2D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Antiretinale Antikorper assoziiert mit zystoidem Makulaodem. [Antiretinal antibodies associated with cystoid macular edema]
Périodique
Klinische Monatsblatter fur Augenheilkunde
Auteur⸱e⸱s
Wolfensberger  T. J., Aptsiauri  N., Godley  B., Downes  S., Bird  A. C.
ISSN
0023-2165 (Print)
Statut éditorial
Publié
Date de publication
05/2000
Volume
216
Numéro
5
Pages
283-5
Notes
English Abstract
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
AIM: Recently, anti-Enolase and anti-carbonic anhydrase antibodies have been observed in over 60% of patients with retinitis pigmentosa (RP) and cystoid macular oedema (CME). We investigated the presence of these antibodies in a series of patients with CME due to different pathologies. METHODS: In 10 patients with CME serum antibodies against Carbonic anhydrase (CA) II (30 kD) and Enolase (46 kD) were sought using Western Blots, Dot Blots as well as ELISA. RESULTS: Western and dot blotting showed anti-CA II antibodies in all and anti-Enolase antibodies in six of the 10 patients. The average titer measured with ELISA was 0.9 +/- 0.08 OD Units (0.35-1.4) with a dilution of 1:400. CONCLUSION: The presence of anti-retinal antibodies in the serum of all patients confirms the high prevalence of these antibodies in patients with CME. This may suggest that a dysfunction of CA and enolase activity in the retinal pigment epithelium may lie at the root of oedema formation, whereas other mechanisms may be responsible in the absence of these antibodies.
Mots-clé
Adult Autoantibodies/*immunology Blotting, Western Carbonic Anhydrases/*immunology Enzyme-Linked Immunosorbent Assay Female Humans Immunoblotting Macular Edema, Cystoid/etiology/*immunology Male Phosphopyruvate Hydratase/*immunology Retina/enzymology/*immunology
Pubmed
Web of science
Création de la notice
28/01/2008 13:05
Dernière modification de la notice
20/08/2019 15:11
Données d'usage