FMRI and intra-cranial electrocorticography recordings in the same human subjects reveals negative BOLD signal coupled with silenced neuronal activity.
Détails
Télécharger: 34363092_BIB_A646D0B25BDE.pdf (3742.01 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_A646D0B25BDE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
FMRI and intra-cranial electrocorticography recordings in the same human subjects reveals negative BOLD signal coupled with silenced neuronal activity.
Périodique
Brain structure & function
ISSN
1863-2661 (Electronic)
ISSN-L
1863-2653
Statut éditorial
Publié
Date de publication
05/2022
Peer-reviewed
Oui
Volume
227
Numéro
4
Pages
1371-1384
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Positive blood oxygenation level-dependent (BOLD) responses (PBR), as measured by functional Magnetic Resonance Imaging (fMRI), are the most utilized measurements to non-invasively map activity in the brain. Recent studies have consistently shown that BOLD responses are not exclusively positive. Negative BOLD responses (NBR) have been reported in response to specific sensory stimulations and tasks. However, the exact relationship between NBR and the underlying metabolic and neuronal demand is still under debate. In this study, we investigated the neurophysiological basis of negative BOLD using fMRI and intra-cranial electrophysiology (electrocorticography, ECoG) measurements from the same human participants. We show that, for those electrodes that responded to visual stimulation, PBR are correlated with high-frequency band (HFB) responses. Crucially, NBR were associated with an absence of HFB power responses and an unpredicted decrease in the alpha power responses.
Mots-clé
Brain Mapping/methods, Electrocorticography/methods, Humans, Magnetic Resonance Imaging/methods, Photic Stimulation, Research Subjects, ECoG, Negative BOLD, Neuronal activity, Positive BOLD
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/08/2021 15:26
Dernière modification de la notice
23/01/2024 7:31